Signalling pathways for sexual differentiation of apicomplexan parasites

顶端复门寄生虫性别分化的信号通路

• 批准号: DP180103212
• 负责人: Prof Dr Alexander Maier
• 金额: $ 35.08万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-05-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180103212
• 关键词: Signalling; pathways; sexual; differentiation; apicomplexan

This project aims to study the sexual development of apicomplexan parasites, which cause major diseases in humans, livestock and wildlife, including malaria. Only sexually differentiated cells can survive in the mosquito vector and hence this development is essential for the parasite's life-cycle. This project will employ a new approach that separates female from male parasites, thus enabling new information to be gleaned about the development of these parasites. The expected outcomes are an understanding of the mechanisms of sexual differentiation and a functional characterisation of novel sex-specific molecules. This will provide significant benefits, such as pivotal prerequisites for new approaches to parasite intervention.

该项目旨在研究顶端复合体寄生虫的性发育，这种寄生虫会导致人类、牲畜和野生动物的主要疾病，包括疟疾。只有性分化的细胞才能在蚊子媒介中存活，因此这种发育对寄生虫的生命周期至关重要。该项目将采用一种新的方法，将雌性和雄性寄生虫分开，从而能够收集关于这些寄生虫发展的新信息。预期的结果是理解性别分化的机制，以及新的性别特异性分子的功能特征。这将带来显著的好处，例如为新的寄生虫干预方法提供关键的先决条件。