PERMEABILITY OF HYPERPLASTIC AND HYPERKERATOTIC ORAL EPITHELIUM

增生性和角化过度的口腔上皮的渗透性

• 批准号: 3839482
• 负责人: CHRISTOPHER A SQUIER
• 金额: --
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3839482
• 关键词: Candida; animal tissue; biopsy; carbon; epithelium; histopathology; human subject; human tissue; keratosis; lichen planus; membrane permeability; oral mucosa; oral pharyngeal hyperplasia; radionuclides; radiotracer; tritium

The oral mucosa lining the oral cavity represents a barrier that limits the access of exogenous material to the underlying tissues. Measurements of permeability of the tissue in man and experimental animals indicates that there is considerable variation between different oral regions. Such variation might explain the susceptibility of certain oral regions to disease, where an extrinsic etiology, such as tobacco or alcohol, is involved. A question that arises is whether common pathological conditions of the mucosa such as hyperplasia and hyperkeratosis, which are known to represent a higher risk of malignant disease than unaltered mucosa, are areas of high permeability. The hypotheses underlying the research is that any agent coming in contact with the surface of the oral mucosa must first penetrate the permeability barrier of the epithelium before it can exert a local effect. The specific aim is to determine whether the permeability of human oral mucosa is modified in areas of epithelial alteration, such a hyperplasia and hyperkeratosis. The research will involve the use of methods to measure permeability using specific radiolabeled tracers. Procedures will be modified to permit the use of small (4 mm diameter) biopsies of human oral mucosa. The outcomes will provide important information on the etiology of mucosal disease and will permit investigation of conditions in which increased permeability may be an important etiologic factor.

口腔内的口腔粘膜代表着一种屏障，限制了 外源物质进入底层组织的途径。测量 组织在人体和实验动物体内的渗透性表明 不同的口腔区域之间有相当大的差异。是这样的 变异可能解释了某些口腔区域对 疾病，如烟草或酒精等外在病因 牵涉其中。由此产生的一个问题是，常见的病理情况 粘膜，如增生和过度角化，这是已知的 比未改变的粘膜具有更高的恶性疾病风险 渗透率高的地区。这项研究的基本假设是 任何接触口腔粘膜表面的试剂都必须首先 穿透上皮的通透性屏障，然后才能发挥作用 局部效应。其具体目的是确定是否存在渗透性 人类口腔粘膜在上皮改变的区域被修饰，例如 增生性角化和过度角化。这项研究将涉及使用 方法使用特定的放射性标记示踪剂测量渗透性。 将修改程序以允许使用小直径(4 mm直径) 人类口腔粘膜的活组织检查。结果将提供重要的 关于粘膜疾病的病因的信息，并将允许 对渗透率增加可能是一种 重要的病因。