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Virus transmission dynamics and the immune response of birds to avian influenza.

病毒传播动力学和鸟类对禽流感的免疫反应。

基本信息

批准号：
BB/E011691/1
负责人：
Colin Butter
金额：
$ 195.51万
依托单位：
The Pirbright Institute
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2009
资助国家：
英国
起止时间：
2009 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FE011691%2F1
关键词：
Virus transmission dynamics immune response

项目摘要

The global spread of H5N1 highly pathogenic avian influenza viruses and their ability to infect not only birds but humans emphasises that human and animal health are unavoidably linked. At present avian influenza remains an animal disease problem under urgent need for control but control in birds will also reduce the potential for a human influenza pandemic. Our knowledge of the behaviour of avian influenza viruses in domestic fowl and wild birds is limited. This proposal poses some fundamental questions that address how the easily the virus can infect chickens, turkeys and ducks; how much, and for how long, virus is shed following infection in each species; and how avian influenza virus infection is controlled by the immune response of birds. Fundamental studies of this type will be critical to the design and implementation of control measures in the short term and the long term.

H5 N1高致病性禽流感病毒在全球的传播及其不仅感染鸟类而且感染人类的能力，突出表明人类和动物的健康密切相关。目前，禽流感仍然是一个迫切需要控制的动物疾病问题，但对鸟类的控制也将降低人类流感大流行的可能性。我们对禽流感病毒在家禽和野鸟中的行为的了解有限。这一提议提出了一些基本问题，这些问题涉及病毒如何容易感染鸡、火鸡和鸭;感染后病毒在每个物种中传播多少和持续多久;以及禽流感病毒感染如何通过鸟类的免疫反应控制。这类基础研究对于短期和长期控制措施的设计和执行至关重要。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Towards a universal vaccine for avian influenza: protective efficacy of modified Vaccinia virus Ankara and Adenovirus vaccines expressing conserved influenza antigens in chickens challenged with low pathogenic avian influenza virus.

DOI：
10.1016/j.vaccine.2012.11.047
发表时间：
2013-01-11
期刊：
VACCINE
影响因子：
5.5
作者：
Boyd, Amy C.;Ruiz-Hernandez, Raul;Peroval, Marylene Y.;Carson, Connor;Balkissoon, Devanand;Staines, Karen;Turner, Alison V.;Hill, Adrian V. S.;Gilbert, Sarah C.;Butter, Colin
通讯作者：
Butter, Colin

Host genetics determine susceptibility to avian influenza infection and transmission dynamics.

DOI：
10.1038/srep26787
发表时间：
2016-06-09
期刊：
Scientific reports
影响因子：
4.6
作者：
Ruiz-Hernandez R;Mwangi W;Peroval M;Sadeyen JR;Ascough S;Balkissoon D;Staines K;Boyd A;McCauley J;Smith A;Butter C
通讯作者：
Butter C

An infected chicken kidney cell co-culture ELISpot for enhanced detection of T cell responses to avian influenza and vaccination.