Do genetic polymorphisms in a beta-carotene metabolising key enzyme influence dietary Vitamin A requirements?
β-胡萝卜素代谢关键酶的遗传多态性是否会影响膳食维生素 A 的需求?
基本信息
- 批准号:BB/G004056/1
- 负责人:
- 金额:$ 38万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2009
- 资助国家:英国
- 起止时间:2009 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Vitamin A (retinol) is an essential nutrient for vision, embryonic development, maturity of organs, cellular proliferation and the immune response. It is obtained from the diet per se or through provitamin A sources that are cleaved enzymatically in the body to produce retinol. Vitamin A deficiency occurs largely due to increases in physiological requirements (growth, pregnancy, lactation, infection) together with a low dietary intake. Currently, the mean daily intake of vitamin A is below the recommended intake levels for men and women aged 19 to 24 years. This means that young individuals in the UK rely to over 50% on provitamin A sources, beta-carotene being the main one, to cover their vitamin A needs. Since a significant proportion of young British individuals have a low vitamin A intake and since the Expert Group on Vitamins and Minerals has recommended to limit the use of beta-carotene in food supplements, there is growing concern that young men and women in the UK might develop subclinical deficiencies, therefore increasing their susceptibility to infectious diseases. This concern is especially valid for young pregnant women who will experience a higher physiological need for vitamin A. Given the fact that a high proportion of the British population relies on beta carotene to cover their vitamin A needs, it is important to note that the amount of retinol produced after ingestion and conversion of beta-carotene is highly variable between healthy individuals. Several studies have shown a large disparity between individuals who are efficient or inefficient converters of beta-carotene, with variations of up to 8 fold. It is possible that the observed differences in obtaining retinol from beta-carotene may be due to genetic polymorphisms in genes involved in aspects of beta-carotene conversion. Indeed, results from our laboratory have shown that two genetic variants exists in the key enzyme responsible for beta-carotene conversion with high frequencies, and that individuals inheriting this genetic trait (1 in 4 of the UK population) might need to increase their intake of preformed Vitamin A sources. The proposed study therefore plans to carry out a human intervention trial using state-of-the art whole body metabolic measurements to identify if individuals carrying this genetic variation might be at a higher risk of developing subclinical vitamin A deficiency. The study is designed to answer the following questions: 1) Have individuals with a genetic variation a reduced capacity of producing retinol from beta carotene when it is consumed at concentrations found in the diet? 2) Are there differences between men and women in their ability to produce retinol from provitamin A sources? 3) Is the intestine the main organ responsible for producing retinol from provitamin A sources, or is the conversion also occuring in other organs at comparable rates?
维生素A(视黄醇)是视力、胚胎发育、器官成熟、细胞增殖和免疫反应的必需营养素。维生素A来源于饮食本身或维生素A原,维生素A原在体内被酶裂解产生视黄醇。维生素A缺乏症的发生主要是由于生理需求的增加(生长,怀孕,哺乳,感染)以及饮食摄入量低。目前,维生素A的平均日摄入量低于19至24岁男女的建议摄入量。这意味着英国的年轻人依赖于超过50%的维生素A原来源,β-胡萝卜素是主要来源,以满足他们的维生素A需求。由于相当大比例的英国年轻人维生素A摄入量较低,而且维生素和矿物质专家组建议限制在食品补充剂中使用β-胡萝卜素,因此人们越来越担心英国的年轻男女可能会出现亚临床缺乏症,从而增加他们对传染病的易感性。这种担忧对于年轻的孕妇尤其有效,因为她们对维生素A的生理需求更高。鉴于英国人口中有很高比例依赖β-胡萝卜素来满足维生素A的需求,重要的是要注意,摄入和转化β-胡萝卜素后产生的视黄醇量在健康个体之间存在很大差异。几项研究表明,有效或无效的β-胡萝卜素转化者之间存在巨大差异,差异高达8倍。从β-胡萝卜素中获得视黄醇所观察到的差异可能是由于β-胡萝卜素转化相关基因的遗传多态性。事实上,我们实验室的结果表明,负责β-胡萝卜素转化的关键酶中存在两种遗传变异,并且遗传这种遗传性状的个体(英国人口中的1/4)可能需要增加预先形成的维生素A来源的摄入量。因此,拟议的研究计划使用最先进的全身代谢测量进行人类干预试验,以确定携带这种遗传变异的个体是否可能具有更高的亚临床维生素A缺乏症风险。这项研究旨在回答以下问题:1)当β-胡萝卜素以饮食中发现的浓度摄入时,具有遗传变异的个体从β-胡萝卜素中产生视黄醇的能力是否降低?2)男性和女性从维生素A原中产生视黄醇的能力是否存在差异?3)肠道是负责从维生素原A来源产生视黄醇的主要器官,还是其他器官也以类似的速度发生转化?
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A Retinol Isotope Dilution Equation Predicts Both Group and Individual Total Body Vitamin A Stores in Adults Based on Data from an Early Postdosing Blood Sample.
- DOI:10.3945/jn.116.233676
- 发表时间:2016-10
- 期刊:
- 影响因子:0
- 作者:Green MH;Ford JL;Green JB;Berry P;Boddy AV;Oxley A;Lietz G
- 通讯作者:Lietz G
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Georg Lietz其他文献
Updated Estimates of Vitamin a Total Body Stores in Healthy Young Adults Determined by Compartmental Modeling with Vitamin a Intake Added as Data (FS06-07-19)
- DOI:
10.1093/cdn/nzz029.fs06-07-19 - 发表时间:
2019-06-01 - 期刊:
- 影响因子:
- 作者:
Jennifer Ford;Georg Lietz;Anthony Oxley;Joanne Green;Michael Green - 通讯作者:
Michael Green
Development of a Screening Tool to Estimate Vitamin A Intake and Comparison with Detailed Dietary Assessment Methods
- DOI:
10.1093/cdn/nzaa043_033 - 发表时间:
2020-06-01 - 期刊:
- 影响因子:
- 作者:
Reina Engle-Stone;Jody Miller;Ame Stormer;Dolly Reario;Mario Capanzana;Carl Cabanilla;Jennifer Ford;Georg Lietz;Marjorie Haskell - 通讯作者:
Marjorie Haskell
Response of Nutritional Biomarkers in Bangladeshi Subjects Given an Immunological Challenge (P10-096-19)
- DOI:
10.1093/cdn/nzz034.p10-096-19 - 发表时间:
2019-06-01 - 期刊:
- 影响因子:
- 作者:
Neal Craft;Francisco Arredondo;Matthew Fleshman;Shaikh Meshbahuddin Ahmad;Jahangir Alam;Nure Afsar;Georg Lietz - 通讯作者:
Georg Lietz
The Influence of Vitamin a on Molecular Bio-mineral Tissue Development in Pigs (P02-012-19)
- DOI:
10.1093/cdn/nzz029.p02-012-19 - 发表时间:
2019-06-01 - 期刊:
- 影响因子:
- 作者:
Adam Clark;Ilias Kyriazakis;Tim Giles;Neil Foster;Georg Lietz - 通讯作者:
Georg Lietz
Assessment of Vitamin A (VA) Total Body Stores (TBS) Using Dried Derum Spots (DSS)
- DOI:
10.1093/cdn/nzaa053_066 - 发表时间:
2020-06-01 - 期刊:
- 影响因子:
- 作者:
Georg Lietz;Anthony Oxley;Reina Engle-Stone;Jody Miller;Dolly Reario;Ame Stormer;Mario Capanzana;Carl Cabanilla;Marjorie Haskell - 通讯作者:
Marjorie Haskell
Georg Lietz的其他文献
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{{ truncateString('Georg Lietz', 18)}}的其他基金
Development and potential reversal of type 2 diabetes: How critical is vitamin A in the regulation of insulin responsiveness and lipid homeostasis?
2 型糖尿病的发展和潜在逆转:维生素 A 在调节胰岛素反应性和脂质稳态方面有多重要?
- 批准号:
MR/T008652/1 - 财政年份:2019
- 资助金额:
$ 38万 - 项目类别:
Research Grant
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