SPECIALIZED CENTER OF RESEARCH IN OSTEOARTHRITIS

骨关节炎专业研究中心

• 批准号: 3105220
• 负责人: ROBY C THOMPSON
• 金额: $ 67.93万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1993-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105220
• 关键词: biomechanics; cartilage disorder; joint disorder; knee; osteoarthritis

The vast majority of clinically evident osteoarthritis remains either idiopathic or related to some mechanical aberration in the joint stability or alignment. We propose that the osteoarthritic process is characterized by disturbance in the equilibrium between mechanical demands on the joint and the ability of joint tissues to support or adapt to those demands. Four individual projects are proposed to test this hypothesis. Project One further extends observations on the blunt impact animal model where the patellofemoral joint is loaded noninvasively by an externally applied force. This project will be utilized to study the cartilage damage and repair, the biology of the zone of calcified cartilage, and the response of subchondral bone. Project Two will study the canine spinal facet joints as an osteoarthritic model using dissolution of the intervertebral disc as an initiating agent to produce changes in the facet joints leading to degenerative arthritis. Biomechanical evaluation of forces and motions in the facet joints will be performed in vivo. Project Three will extend the study of excessive joint motion to humans, evaluating patients with anterior cruciate ligament deficient knees and normal subjects using a six-degree-of- freedom electrogoniometer during functional tasks. The possibility that neuromuscular control of the joint may influence the stability of the knee will be extended from Project Three to Project Four where the role of ligament and capsular innervation as an influencing element in joint stability and function will be studied in dogs.

绝大多数临床明显的骨性关节炎仍然存在 要么是特发性的，要么是与某些机械异常有关的 关节的稳定性或对齐。我们认为骨性关节炎 过程的特征是平衡中的扰动。 关节力学要求与关节能力之间的关系 纸巾来支持或适应这些需求。四个人 提出了一些项目来检验这一假说。项目一 进一步扩大对钝性撞击动物模型的观察 其中，髌股关节由一种非侵入性的 外力外力。该项目将被用于研究 软骨的损伤和修复，关节区的生物学 软骨钙化，软骨下骨反应。 项目二将研究犬脊柱小关节作为 腰椎间盘溶解法制备骨关节炎模型 作为引发剂在小关节中产生变化 导致退行性关节炎。椎弓根骨折的生物力学评价 小关节中的力和运动将在体内进行。 项目三将把关节过度运动的研究扩展到 人类，评估前十字韧带患者 膝关节缺陷和正常受试者使用六度角- 功能任务中的自由电子测角仪。这个 关节的神经肌肉控制可能会影响 膝关节的稳定性将从项目三延长到 方案四，韧带和包膜神经的作用 作为影响关节稳定性和功能的因素， 在狗身上研究。