SPECIALIZED CENTER OF RESEARCH IN OSTEOARTHRITIS

绝大多数临床上明显的骨关节炎仍然是 要么是特发性的，要么是与大脑中的一些机械畸变有关的。 关节稳定性或对齐。 我们认为骨关节炎 过程的特征是平衡中的扰动 关节的力学要求和关节的能力之间的关系 组织来支持或适应这些需求。 四个单独 提出了一些项目来检验这一假设。 Project One 进一步扩展了对钝头撞击动物模型的观察 其中髌股关节由非侵入性的 外部施加的力。 该项目将用于研究 软骨损伤和修复， 钙化软骨和软骨下骨的反应。 项目二将研究犬脊柱小关节作为一种 使用椎间盘溶解的骨关节炎模型 作为引发剂以产生小关节的变化 导致退化性关节炎 的生物力学评价 小平面关节中的力和运动将在体内进行。 项目三将扩展过度关节运动的研究， 人类，评估前交叉韧带患者 缺陷膝关节和正常受试者使用六度- 在功能任务期间使用Freedom电测角仪。 的 关节的神经肌肉控制可能影响 膝关节的稳定性将从项目三延长到 项目四其中韧带和囊神经支配的作用 作为关节稳定性和功能的影响因素， 在狗身上研究。

The vast majority of clinically evident osteoarthritis remains either idiopathic or related to some mechanical aberration in the joint stability or alignment. We propose that the osteoarthritic process is characterized by disturbance in the equilibrium between mechanical demands on the joint and the ability of joint tissues to support or adapt to those demands. Four individual projects are proposed to test this hypothesis. Project One further extends observations on the blunt impact animal model where the patellofemoral joint is loaded noninvasively by an externally applied force. This project will be utilized to study the cartilage damage and repair, the biology of the zone of calcified cartilage, and the response of subchondral bone. Project Two will study the canine spinal facet joints as an osteoarthritic model using dissolution of the intervertebral disc as an initiating agent to produce changes in the facet joints leading to degenerative arthritis. Biomechanical evaluation of forces and motions in the facet joints will be performed in vivo. Project Three will extend the study of excessive joint motion to humans, evaluating patients with anterior cruciate ligament deficient knees and normal subjects using a six-degree-of- freedom electrogoniometer during functional tasks. The possibility that neuromuscular control of the joint may influence the stability of the knee will be extended from Project Three to Project Four where the role of ligament and capsular innervation as an influencing element in joint stability and function will be studied in dogs.