EPILEPSY RESEARCH CENTER

癫痫研究中心

• 批准号: 3107621
• 负责人: PETER A KELLAWAY
• 金额: $ 129.17万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-06-01 至 1992-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3107621
• 关键词: epilepsy

This is a multidisciplinary research program, employing innovative analytical methods for the study of interrelated neurophysiological, biochemical, and pharmacological aspects of epilepsy. In the clinically oriented research, analysis of temporal variabilities and biorhythms of clinical and electrical epileptic activity over time examines therapeutic response in a parametric design as a function of epileptic class, drug levels, clinical seizure incidence, and epileptiform EEG activity. Design and application of computer-based systems to improve EEG detection, characterization, and quantification of the epileptic process is a major aspect of the research program, as is the design and application of multimicroprocessor-based systems for the cost-effective analysis of data from prolonged monitoring studies. A specically designed time-synchronized, polygraphic recording and video-tape system is utilized to evaluate the effectiveness of the ACTH fragment (4-9) in the treatment of infantile spasms and to determine if the effectiveness of ACTH is mediated via the adrenal axis or by direct action on the brain. Fundamental studies employ in vitro hippocampal-slice techniques to elucidate membrane and synaptic mechanisms in epileptogenesis and the mechanisms of action of anticonvulsant and convulsant agents. The influence of epileptic seizures on neurogenic control and metabolic exchange of the cerebral microvasculature is examined in pentylenetetrazol-induced seizures in the rat, and the pathophysiological mechanisms involved in the elaboration of clinical and electrical seizures are studied in a new generalized-epilepsy model.

这是一个多学科的研究项目，采用创新的分析方法