EPILEPSY RESEARCH CENTER
EPILEPSY RESEARCH CENTER
批准号:
2036988
负责人:
PETER A KELLAWAY
金额:
$67.56万
依托单位国家:
美国
项目类别:
财政年份:
1978
资助国家:
美国
项目状态:
已结题
起止时间:
1978-06-01 至 1998-11-30
中文摘要
这个多学科的研究项目结合了各种分析
英文摘要
This multidisciplinary research program combines various analytic
techniques to investigate the synaptic physiology, biophysics, and
biochemistry of epileptogenesis and the development of the epileptic
process in mammalian brain. The goal is to apply new methods of
selectively measuring excitability changes at excitatory synapses,
second-messenger modulation of inhibitory synaptic transmission, and
axonal sprouting in specific neural networks to determine whether key
excitability defects in epileptic brain are mediated by use-dependent and
potentially reversible mechanisms.
The research tests specific hypotheses extending from the molecular to
the structural levels of neural organization, and is based on three model
systems. (1) Acute epileptogenesis, using hippocampal slice techniques,
will be studied with a focus on the immediate role of use-dependent
plastic properties of recurrent excitatory synapses in the CA3 subfield
and on long-term potentiation in the generation of epileptiform activity.
(2) Chronic focal epileptogenesis, using slices from kindled animals,
will be studied to determine the functional consequences of aberrant
mossy fiber growth during prolonged abnormal stimulation. (3) Inherited
generalized epileptogenesis, using slices from epileptic mice with
single-locus genetic mutations, will be studied to examine synaptic and
biochemical mechanisms underlying network bursting, modulation of GABA-
receptor-mediated inhibition, and aberrant axonal sprouting and
neosynaptogenesis.
A critical element of this research program is the high degree of
interaction and collaboration, at both technical and conceptual levels,
among the scientists who comprise the research team.
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Alternate endpoint: EEG assessment of antiepileptic drug efficacy and toxicity.
替代终点:脑电图评估抗癫痫药物的疗效和毒性。
DOI:
--
发表时间:
1998
期刊:
Advances in neurology.
影响因子:
--
作者:
[Mizrahi,EM]
通讯作者:
Mizrahi,EM
Effects of phenytoin on pyramidal neurons of the rat hippocampus.
苯妥英对大鼠海马锥体神经元的影响。
DOI:
10.1016/0006-8993(81)90582-5
发表时间:
1981
期刊:
Brain research
影响因子:
2.9
作者:
[Hershkowitz,N, Ayala,GF]
通讯作者:
Ayala,GF
Persistent hypersynchronization of neocortical neurons in the mocha mutant of mouse.
小鼠摩卡突变体中新皮质神经元的持续超同步。
DOI:
10.3109/01677068909107100
发表时间:
1989
期刊:
Journal of neurogenetics
影响因子:
1.9
作者:
[Noebels,JL, Sidman,RL]
通讯作者:
Sidman,RL
Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisone.
在 ACTH 和泼尼松对照研究中治疗婴儿痉挛症婴儿结局的前瞻性研究。
DOI:
10.1016/s0022-3476(88)80318-4
发表时间:
1988
期刊:
The Journal of pediatrics
影响因子:
--
作者:
[Glaze,DG, Hrachovy,RA, FrostJr,JD, Kellaway,P, Zion,TE]
通讯作者:
Zion,TE
Clinical and neurophysiologic correlates of neonatal seizures.
新生儿癫痫发作的临床和神经生理学相关性。
DOI:
10.3949/ccjm.56.s1.100
发表时间:
1989
期刊:
Cleveland Clinic journal of medicine
影响因子:
6.1
作者:
[Mizrahi,EM]
通讯作者:
Mizrahi,EM
共 59 条
EPILEPSY RESEARCH CENTER
-
批准号:3099369
-
项目类别:
-
资助金额:$41.77万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
EPILEPSY RESEARCH CENTER
-
批准号:3107630
-
项目类别:
-
资助金额:$108.25万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
EPILEPSY RESEARCH CENTER
-
批准号:3107628
-
项目类别:
-
资助金额:$137.31万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
EPILEPSY RESEARCH CENTER
-
批准号:3107627
-
项目类别:
-
资助金额:$124.67万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
EPILEPSY RESEARCH CENTER
-
批准号:3107622
-
项目类别:
-
资助金额:$19.41万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
EPILEPSY RESEARCH CENTER
-
批准号:3107626
-
项目类别:
-
资助金额:$80.01万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
EPILEPSY RESEARCH CENTER
-
批准号:2262320
-
项目类别:
-
资助金额:$45.39万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
EPILEPSY RESEARCH CENTER
-
批准号:3107629
-
项目类别:
-
资助金额:$122.7万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
EPILEPSY RESEARCH CENTER
-
批准号:2262322
-
项目类别:
-
资助金额:$64.97万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
EPILEPSY RESEARCH CENTER
-
批准号:3107621
-
项目类别:
-
资助金额:$129.17万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
EPILEPSY RESEARCH CENTER
-
批准号:2262319
-
项目类别:
-
资助金额:$43.57万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
EPILEPSY RESEARCH CENTER
-
批准号:3107625
-
项目类别:
-
资助金额:$100.72万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
EPILEPSY RESEARCH CENTER
-
批准号:2262321
-
项目类别:
-
资助金额:$20.3万
-
财政年份:1978
-
负责人:PETER A KELLAWAY
-
依托单位:
TREATMENT OF INFANTILE SPASMS WITH ACTH 4-9
-
批准号:4702473
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:PETER A KELLAWAY
-
依托单位:
TIME MODULATION OF EPILEPTIC ACITVITY IN THE BRAIN
-
批准号:3882015
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:PETER A KELLAWAY
-
依托单位:
PATHOPHYSIOLOGICAL STUDIES IN NEONATAL SEIZURES
-
批准号:3901759
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:PETER A KELLAWAY
-
依托单位:
ANTIEPILEPTIC DRUG LABORATORY CORE
-
批准号:3861083
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:PETER A KELLAWAY
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依托单位:
ANTIEPILEPTIC DRUG LABORATORY CORE
-
批准号:3922823
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:PETER A KELLAWAY
-
依托单位:
ANTIEPILEPTIC DRUG LABORATORY CORE
-
批准号:3945560
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:PETER A KELLAWAY
-
依托单位:
TIME MODULATION OF EPILEPTIC ACITVITY IN THE BRAIN
-
批准号:4697228
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:PETER A KELLAWAY
-
依托单位:
海外基金