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EPILEPSY RESEARCH CENTER

癫痫研究中心

基本信息

批准号：
3107630
负责人：
PETER A KELLAWAY
金额：
$ 108.25万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
起止时间：
1978-06-01 至 1993-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3107630
关键词：
epilepsy

项目摘要

This is a multidisciplinary research program, employing innovative analytical methods for the study of interrelated neurophysiological, biochemical, and pharmacological aspects of epilepsy. In the clinically oriented research, analysis of temporal variabilities and biorhythms of clinical and electrical epileptic activity over time examines therapeutic response in a parametric design as a function of epileptic class, drug levels, clinical seizure incidence, and epileptiform EEG activity. Design and application of computer-based systems to improve EEG detection, characterization, and quantification of the epileptic process is a major aspect of the research program, as is the design and application of multimicroprocessor-based systems for the cost-effective analysis of data from prolonged monitoring studies. A specically designed time-synchronized, polygraphic recording and video-tape system is utilized to evaluate the effectiveness of the ACTH fragment (4-9) in the treatment of infantile spasms and to determine if the effectiveness of ACTH is mediated via the adrenal axis or by direct action on the brain. Fundamental studies employ in vitro hippocampal-slice techniques to elucidate membrane and synaptic mechanisms in epileptogenesis and the mechanisms of action of anticonvulsant and convulsant agents. The influence of epileptic seizures on neurogenic control and metabolic exchange of the cerebral microvasculature is examined in pentylenetetrazol-induced seizures in the rat, and the pathophysiological mechanisms involved in the elaboration of clinical and electrical seizures are studied in a new generalized-epilepsy model.

这是一个多学科的研究计划，采用创新的分析，研究相关神经生理学、生物化学和癫痫的治疗方法在临床导向研究中，临床和电生理的时间变异性和生物节律分析随着时间的推移，癫痫活动检查参数中的治疗反应，设计为癫痫类别、药物水平、临床发作的函数发病率和癫痫样EEG活动。设计和应用基于计算机的系统，以改善EEG检测，表征和量化癫痫过程是一个主要方面，的研究计划，因为是设计和应用以多微处理机为基础的系统，长期监测研究。一种特殊设计的时间同步，多道记录和录像带系统用于评估ACTH片段（4-9）在婴儿痉挛症的治疗，并确定是否有效的ACTH 通过肾上腺轴或直接作用于大脑来调节。基础研究采用体外细胞切片技术来阐明癫痫发生中的膜和突触机制及其作用机制抗惊厥剂和抗惊厥剂的混合物。癫痫发作对人的影响脑微血管的神经原性控制和代谢交换是在戊四氮诱导的大鼠癫痫发作中检查，病理生理机制参与制定的临床和在一种新的全身性癫痫模型中研究电癫痫发作。