MSc in Toxicology

毒理学硕士

• 批准号: BB/H020586/1
• 负责人: Anne Pheasant
• 金额: $ 51.84万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Training Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FH020586%2F1
• 关键词: MSc; Toxicology

The programme consists of 6 taught modules (120 credits) and a research dissertation (60 credits) as outline in the progamme specification. TAUGHT MODULES take place between October and May and are as follows: 1: Metabolism and excretion of xenobiotics: 20 credits Literature retrieval, computer data bases, communication skills. ADME; metabolic pathways, phase I and II reactions; polymorphisms; effect of age sex, genotype. Methods used to study drug metabolism including application of molecular biology techniques to drug metabolism and toxicogenetics. Metabolism and distribution as a basis for toxicity of xenobiotics. Drug transporters. 2: Pharmacological and clinical aspects of toxicology: 20 credits Principles and applications pf pharmacokinetics, pharmacodynamics, pharmacogenetics. Safety pharmacology. Adverse reactions to drugs; drug development. Forensic toxicology; detection of drugs and toxins, post mortem investigations. Clinical toxicology; diagnosis, complications, management of poisonings. 3: Molecular and cellular mechanisms of toxicity and carcinogenesis: 20 credits Molecular mechanisms of toxicity; necrosis and apoptosis. Application of molecular and cell biology to toxicology; cDNA arrays, stress responses, reporter gene assays. Toxicogenomics, proteomics, metabolomics, bioinformatics. Receptor mediated toxicity. Mechanisms of carcinogenesis; genotoxic vs nongenotoxic. In vitro testing. Immunotoxicity. Nanoparticle toxicology. Computer assisted structure activity relationships. 4: Toxicology in Practice; safety assessment in industry and the environment. 30 credits Pathology of acute and chronic inflammation, degeneration, necrosis, neoplasia, atrophy and hypertrophy. Histology, Haematology. Respiratory toxicity, hepatotoxicity, neurotoxicity, nephrotoxicity, reprotoxicity. Use of animals in toxicology. Safety and risk assessment. Statistics. Occupational, environmental and ecotoxicology: Environmental pollutants; land air and water contamination; monitoring, global effects. Pesticides in food. Ecotoxicology; biological effects and biomarkers from molecules to eco systems, examples and case studies including endocrine disruptors and PCBs. Occupational toxicology, epidemiology, risk assessment. Role of regulators such as HSE, FSA. Impact of REACH 5: Skills 10 credits Improves communication, IT, data handling and team working skills and is embedded throughout the programme. Exercises in literature searching/information retrieval, communication of findings in written, oral and poster formats. Experimental design, statistics, computational techniques including bioinformatics and DEREK. Risk assessment exercises. 6; Synoptic. 20 credits Consolidation and integration: time for directed, student-centred learning. Revision. RESEARCH PROJECT: 60 credits 3 months full time; carried out in an appropriate research environment. All modules are compulsory. In addition students are offered the option of completing Modules 1, 2 and 3 of the Home Office training course during the Easter vacation. The taught component is delivered by a combination of formal lectures, tutorials, workshops, computer exercises, practical classes and demonstrations and is supported by directed reading and course work. The programme specification gives details of learning and teaching methods and assessment methods along with knowledge, understanding, skills and attributes the students are expected to attain. Research projects are carried out over a 12 week period in May - August and are typically based in industry, research institutes, environmental agencies, hospitals and universities, in the UK and overseas. The project represents the major practical element of the course during which students have the opportunity to plan their work and analyse and interpret data. Some students opt for research projects that are literature or computer based but all give experience of current problems in toxicology.

该计划包括6个教学模块（120学分）和一篇研究论文（60学分），如计划规范所述。教学模块在10月至5月之间进行，内容如下：1：代谢和排泄异种生物：20学分文献检索，计算机数据库，沟通技巧。ADME;代谢途径，I期和II期反应；多态性;年龄、性别、基因型的影响。研究药物代谢的方法，包括分子生物学技术在药物代谢和毒物遗传学中的应用。代谢和分布是研究外源性药物毒性的基础。药物转运蛋白。2：药理学和临床毒理学：20学分药代动力学、药效学、药物遗传学的原理和应用。安全药理学。药物不良反应；药物开发。法医毒理学;毒品和毒素检测，尸检调查。临床毒理学;诊断，并发症，中毒处理。3 .毒性和癌变的分子和细胞机制：20学分；坏死和细胞凋亡。分子细胞生物学在毒理学研究中的应用cDNA阵列，应激反应，报告基因分析。毒物基因组学，蛋白质组学，代谢组学，生物信息学。受体介导毒性。致癌机制；基因毒性与非基因毒性。体外测试。免疫毒性。纳米毒理学。计算机辅助结构活动关系。4：实践毒理学；工业和环境安全评价。急慢性炎症、变性、坏死、瘤变、萎缩和肥大的病理学。组织学,血液学。呼吸毒性，肝毒性，神经毒性，肾毒性，生殖毒性。动物在毒理学中的应用。安全和风险评估。统计数据。职业、环境和生态毒理学：环境污染物；土地、空气和水污染；监测全球影响。食品中的农药。生态毒理学;从分子到生态系统的生物效应和生物标志物，包括内分泌干扰物和多氯联苯的例子和案例研究。职业毒理学，流行病学，风险评估。监管机构的作用，如HSE， FSA。REACH 5的影响：技能10学分提高沟通、IT、数据处理和团队合作技能，并贯穿整个课程。练习文献检索/信息检索，以书面、口头和海报形式交流研究结果。实验设计，统计学，计算技术，包括生物信息学和DEREK。风险评估练习。6;概要性。20学分巩固与整合：有针对性的、以学生为中心的学习时间。修订。研究项目：60学分，全日制3个月；在适当的研究环境中进行。所有模块都是必修的。此外，学生可以选择在复活节假期完成内政部培训课程的模块1、2和3。授课部分由正式讲座、辅导课、研讨会、计算机练习、实践课程和演示相结合，并辅以指导阅读和课程作业。课程规范详细说明了学习、教学方法和评估方法，以及学生期望获得的知识、理解、技能和属性。研究项目在5月至8月进行，为期12周，通常是在英国和海外的工业、研究机构、环境机构、医院和大学进行的。该项目代表了课程的主要实践元素，在此期间，学生有机会计划他们的工作，分析和解释数据。一些学生选择以文献或计算机为基础的研究项目，但都提供了毒理学当前问题的经验。