OLD-AGE MORTALITY--LIFE-TABLE AGING RATE ANALYSIS

老年死亡率--生命表老龄化率分析

• 批准号: 3122403
• 负责人: SHIRO HORIUCHI
• 金额: $ 1.97万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3122403
• 关键词: aging; epidemiology; gender difference; human data; human morbidity; human mortality; human old age (65+); human population study; mathematical model; model design /development

What are the mechanisms of aging? The study of this fundamental question in gerontology is not limited to laboratory and clinical studies but is extended to demogaphic and epidemiological research, because age patterns of mortality and morbidity reflect some aspects of underlying mechanisms of progressive senescence. Recent studies using the life-table aging rate (LAR), defined as the rate of relative mortality increase with age, show distinct mathematical patterns of all-cause and cause-specific mortality in the first derivative of the logarithm of age-specific death rate. The clarity and regularity of the patterns suggest that they reflect some underlying processes. This project, therefore, will study relationships between aging and mortality through LAR patterns. The following questions are raised: 1. (All-cause mortality) A previous study on the mortality of old women shows that the LAR rises with age at younger old ages and declines with age at older old ages, resulting in a bell-shaped curve peaking around age 75. Why does the LAR follow such a trajectory? 2. (Cause-specific mortality) What age patterns does the LAR exhibit for each of the major causes of death? Do biomedical theories on relationships between aging and disease explain those cause-specific LAR patterns? 3. (Interrelationships) What mechanisms combine different LAR patterns of cause-specific mortality into the bell-shaped LAR curve of all-cause mortality? 4. (Trends) Are there any systematic trends in LAR patterns of all-cause and cause-specific mortality? If so, what explains the trends? 5. (Sex differentials) Are there any sex differentials in LAR patterns of all-cause and cause-specific mortality? If so, what explains the sex differentials? The central aim of this project is to investigate these problems by (a) analyzing internationally compiled data on death rates classified by age, sex and causes of death, (b) linking observed LAR patterns with biomedical theories on aging and disease, and (c) developing mathematical models on relationships between aging, disease and mortality based on results of (a) and (b).

衰老的机制是什么？对这个基本问题的研究