OLD-AGE MORTALITY--LIFE-TABLE AGING RATE ANALYSIS

老年死亡率--生命表老龄化率分析

• 批准号: 3122402
• 负责人: SHIRO HORIUCHI
• 金额: $ 6.5万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3122402
• 关键词: aging; epidemiology; gender difference; human morbidity; human mortality; human old age (65+); human population study; mathematical model; model design /development

What are the mechanisms of aging? The study of this fundamental question in gerontology is not limited to laboratory and clinical studies but is extended to demogaphic and epidemiological research, because age patterns of mortality and morbidity reflect some aspects of underlying mechanisms of progressive senescence. Recent studies using the life-table aging rate (LAR), defined as the rate of relative mortality increase with age, show distinct mathematical patterns of all-cause and cause-specific mortality in the first derivative of the logarithm of age-specific death rate. The clarity and regularity of the patterns suggest that they reflect some underlying processes. This project, therefore, will study relationships between aging and mortality through LAR patterns. The following questions are raised: 1. (All-cause mortality) A previous study on the mortality of old women shows that the LAR rises with age at younger old ages and declines with age at older old ages, resulting in a bell-shaped curve peaking around age 75. Why does the LAR follow such a trajectory? 2. (Cause-specific mortality) What age patterns does the LAR exhibit for each of the major causes of death? Do biomedical theories on relationships between aging and disease explain those cause-specific LAR patterns? 3. (Interrelationships) What mechanisms combine different LAR patterns of cause-specific mortality into the bell-shaped LAR curve of all-cause mortality? 4. (Trends) Are there any systematic trends in LAR patterns of all-cause and cause-specific mortality? If so, what explains the trends? 5. (Sex differentials) Are there any sex differentials in LAR patterns of all-cause and cause-specific mortality? If so, what explains the sex differentials? The central aim of this project is to investigate these problems by (a) analyzing internationally compiled data on death rates classified by age, sex and causes of death, (b) linking observed LAR patterns with biomedical theories on aging and disease, and (c) developing mathematical models on relationships between aging, disease and mortality based on results of (a) and (b).

衰老的机制是什么？对这一根本问题的研究 不仅限于实验室和临床研究，而且是 扩展到人口学和流行病学研究，因为年龄模式 死亡率和发病率反映了潜在机制的某些方面 渐进性衰老。利用寿命表老化的最新研究 死亡率(LAR)，定义为相对死亡率随着年龄的增加而增加， 显示所有原因和特定原因的不同数学模式 年龄别死亡对数的一阶导数中的死亡率 费率。这些图案的清晰度和规律性表明它们 反映一些潜在的过程。 因此，这个项目将研究老龄化和 通过LAR模式的死亡率。提出了以下问题： 1.(全因死亡率)先前一项关于老年妇女死亡率的研究 结果表明，在较年轻的老年，LAR随年龄增长而上升，随着年龄的增长，LAR下降 随着年龄的增大，导致钟形曲线在周围达到峰值 现年75岁。为什么LAR会遵循这样的轨迹？ 2.(特定死因死亡率)LAR表现出什么年龄模式 每一种主要的死因？做生物医学理论的研究 衰老和疾病之间的关系解释了这些特定原因的LAR 模式？ 3.(相互关系)是什么机制结合了不同的LAR模式 全因死因死亡率进入钟形LAR曲线 死亡率？ 4.(趋势)所有原因的LAR模式是否有系统性趋势 和死因相关的死亡呢？如果是这样的话，如何解释这种趋势？ 5.(性别差异)青少年的LAR模式是否存在性别差异 全因死亡和特定原因死亡？如果是这样的话，如何解释性行为 有什么区别吗？ 该项目的中心目标是通过(A)调查这些问题 分析按年龄分类的死亡率的国际汇编数据， 性别和死因，(B)将观察到的LAR模式与 关于衰老和疾病的生物医学理论，以及(C)发展数学 老龄化、疾病和死亡率之间关系的模型 (A)和(B)项的结果。