Expression and formulation of bluetongue virus genes and proteins for development of effective vaccination strategies. THIS GRANT IS A SUPPLEMENTATION

蓝舌病毒基因和蛋白质的表达和配制，用于制定有效的疫苗接种策略。

• 批准号: BB/H531151/1
• 负责人: Peter Mertens
• 金额: $ 8.89万
• 依托单位: The Pirbright Institute
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FH531151%2F1
• 关键词: Expression; formulation; bluetongue; virus; genes

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

Using shared needles for subcutaneous inoculation can transmit bluetongue virus mechanically between ruminant hosts.

• DOI: 10.1038/srep20627
• 发表时间: 2016-02-08
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Darpel KE;Barber J;Hope A;Wilson AJ;Gubbins S;Henstock M;Frost L;Batten C;Veronesi E;Moffat K;Carpenter S;Oura C;Mellor PS;Mertens PP
• 通讯作者: Mertens PP

The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host.

• DOI: 10.1016/j.antiviral.2018.04.015
• 发表时间: 2018-06
• 期刊: Antiviral research
• 影响因子: 7.6
• 作者: Calvo-Pinilla E;Gubbins S;Mertens P;Ortego J;Castillo-Olivares J
• 通讯作者: Castillo-Olivares J

Antiserum from mice vaccinated with modified vaccinia Ankara virus expressing African horse sickness virus (AHSV) VP2 provides protection when it is administered 48h before, or 48h after challenge.

• DOI: 10.1016/j.antiviral.2015.01.009
• 发表时间: 2015-04
• 期刊: Antiviral research
• 影响因子: 7.6
• 作者: Calvo-Pinilla E;de la Poza F;Gubbins S;Mertens PP;Ortego J;Castillo-Olivares J
• 通讯作者: Castillo-Olivares J

Protection of IFNAR (-/-) mice against bluetongue virus serotype 8, by heterologous (DNA/rMVA) and homologous (rMVA/rMVA) vaccination, expressing outer-capsid protein VP2.

• DOI: 10.1371/journal.pone.0060574
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Jabbar TK;Calvo-Pinilla E;Mateos F;Gubbins S;Bin-Tarif A;Bachanek-Bankowska K;Alpar O;Ortego J;Takamatsu HH;Mertens PP;Castillo-Olivares J
• 通讯作者: Castillo-Olivares J