MAST CELL - EOSINOPHIL INTERACTION IN ALLERGIC INJURY

肥大细胞和嗜酸性粒细胞与过敏反应密切相关。 嗜酸性粒细胞过氧化物酶(EPO)与过氧化氢结合时(H202)和 卤化物形成能够启动肥大细胞的强氧化系统。 脱颗粒。EPO也与分泌的肥大细胞颗粒紧密结合。 (MCG)形成具有增强的过氧化活性的络合物。目标 本研究主要包括以下几个方面：1)研究藻类的形成和生物学特性 2)研究MCG-EPO复合体的形成和失活 白三烯的吞噬作用；3)肥大细胞的诱导 粒细胞释放因子的分泌；4)研究相互作用 肥大细胞和嗜酸性粒细胞产物对日本血吸虫幼虫的杀灭作用 曼氏血吸虫和5)肥大细胞肝素降解的研究 粒细胞产品。总体目标是研究桅杆的相互作用。 细胞和嗜酸性粒细胞以及这种相互作用在 过敏性疾病的表现及其在宿主防御中的作用 寄生虫。

Mast cells and eosinophils are closely associated in allergic reactions. Eosinophil peroxidase (EPO) when combined with hydrogen peroxide (H202) and a halide forms a strong oxidative system capable of initiating mast cell degranulation. EPO also binds firmly to the secreted mast cell granules (MCG) to form a complex with augmented peroxidatic activity. Objectives of this research are 1) to study the formation and biological properties of the MCG-EPO complex; 2) to study the formation and inactivation of leukotrienes by phagocytes; 3) to study the induction of mast cell secretion by agents released by granulocytes; 4) to study the interaction of mast cell and eosinophil products in the killing of the schistosomula of Schistosoma mansoni and 5) to study the degradation of mast cell heparin by granulocyte products. The overall aim is to study the interaction of mast cells and eosinophils and the role of this interaction in the manifestations of allergic diseases and in the host defense against parasites.