ADAPTATION OF LEISHMANIA TO NATURAL DIETS OF THE VECTOR
利什曼原虫对媒介自然饮食的适应
基本信息
- 批准号:3147103
- 负责人:
- 金额:$ 10.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1992
- 资助国家:美国
- 起止时间:1992-04-01 至 1995-03-31
- 项目状态:已结题
- 来源:
- 关键词:Leishmania arthropod borne communicable disease communicable disease control communicable disease transmission diet dietary carbohydrates disease vectors endopeptidases environmental adaptation field study host organism interaction leishmaniasis nutrition related tag pathologic process plants proteolysis radiotracer trypsin
项目摘要
Leishmania resides in the alimentary tract of vector sandflies, in a medium
comprising the food of the fly mixed with digestive enzymes. We shall
determine whether variations in the composition of the food influence the
course of development of the pathogen and whether such factor may affect
the natural force of transmission.
One series of experiments will correlate the presence of various naturally
occurring food plants and honeydew, found in the Jordan Valley, with the
course of L. major infection in P. papatasi. First, these foods will be
provided to laboratory-reared infected flies and the effect of each diet
characterized by estimating parasite density, mortality and morphological
abberations, in stained preparations of gut-contents. The criteria deduced
from these experiments will be used to screen putative field diets for
their effect on natural infections in vector flies. Then, we shall
evaluate how frequently each of these foods are ingested in nature, by
examining the guts of wild-caught flies. The prevalence of Leishmania will
be correlated with the presence of particular food sources.
A companion series of experiments will investigate whether blood of
different animals, endemic to the Jordan Valley, affects the course of
infection in sandflies. Thus, we shall determine whether leishmanial
infection is diminished or eliminated after infected flies feed on
particular naturally occurring animals. Because midgut proteolysis in
vector sandflies varies between different kinds of hosts and the major
glycoconjugates of the Leishmania influences these digestive enzymes, we
shall compare the trypsin-like enzymes secreted in sandflies after feeding
on this array of hosts.
The proposed analysis of the diet of the vector as a factor that affects
vector competence and the force of leishmanial transmission constitutes a
novel approach to the epidemiology of the leishmaniases. We anticipate
that these results will contribute to a basic understanding of vector-
pathogen interactions and may provide methods useful in the control of
these infections.
利什曼原虫存在于媒介白蛉的消化道中
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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YOSEF SCHLEIN其他文献
YOSEF SCHLEIN的其他文献
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{{ truncateString('YOSEF SCHLEIN', 18)}}的其他基金
PLANT DIETS OF SANDFLIES AND LEISHMANIA TRANSMISSION
白蛉和利什曼原虫传播的植物饮食
- 批准号:
2462157 - 财政年份:1998
- 资助金额:
$ 10.63万 - 项目类别:
PLANT DIETS OF SANDFLIES AND LEISHMANIA TRANSMISSION
白蛉和利什曼原虫传播的植物饮食
- 批准号:
6149830 - 财政年份:1998
- 资助金额:
$ 10.63万 - 项目类别:
PLANT DIETS OF SANDFLIES AND LEISHMANIA TRANSMISSION
白蛉和利什曼原虫传播的植物饮食
- 批准号:
2871553 - 财政年份:1998
- 资助金额:
$ 10.63万 - 项目类别:
ADAPTATION OF LEISHMANIA TO NATURAL DIETS OF THE VECTOR
利什曼原虫对媒介自然饮食的适应
- 批准号:
3147104 - 财政年份:1992
- 资助金额:
$ 10.63万 - 项目类别:
ADAPTATION OF LEISHMANIA TO NATURAL DIETS OF THE VECTOR
利什曼原虫对媒介自然饮食的适应
- 批准号:
2066975 - 财政年份:1992
- 资助金额:
$ 10.63万 - 项目类别: