ADAPTATION OF LEISHMANIA TO NATURAL DIETS OF THE VECTOR

利什曼原虫对媒介自然饮食的适应

基本信息

  • 批准号:
    3147103
  • 负责人:
  • 金额:
    $ 10.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1992
  • 资助国家:
    美国
  • 起止时间:
    1992-04-01 至 1995-03-31
  • 项目状态:
    已结题

项目摘要

Leishmania resides in the alimentary tract of vector sandflies, in a medium comprising the food of the fly mixed with digestive enzymes. We shall determine whether variations in the composition of the food influence the course of development of the pathogen and whether such factor may affect the natural force of transmission. One series of experiments will correlate the presence of various naturally occurring food plants and honeydew, found in the Jordan Valley, with the course of L. major infection in P. papatasi. First, these foods will be provided to laboratory-reared infected flies and the effect of each diet characterized by estimating parasite density, mortality and morphological abberations, in stained preparations of gut-contents. The criteria deduced from these experiments will be used to screen putative field diets for their effect on natural infections in vector flies. Then, we shall evaluate how frequently each of these foods are ingested in nature, by examining the guts of wild-caught flies. The prevalence of Leishmania will be correlated with the presence of particular food sources. A companion series of experiments will investigate whether blood of different animals, endemic to the Jordan Valley, affects the course of infection in sandflies. Thus, we shall determine whether leishmanial infection is diminished or eliminated after infected flies feed on particular naturally occurring animals. Because midgut proteolysis in vector sandflies varies between different kinds of hosts and the major glycoconjugates of the Leishmania influences these digestive enzymes, we shall compare the trypsin-like enzymes secreted in sandflies after feeding on this array of hosts. The proposed analysis of the diet of the vector as a factor that affects vector competence and the force of leishmanial transmission constitutes a novel approach to the epidemiology of the leishmaniases. We anticipate that these results will contribute to a basic understanding of vector- pathogen interactions and may provide methods useful in the control of these infections.
利什曼原虫存在于媒介白蛉的消化道中

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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YOSEF SCHLEIN其他文献

YOSEF SCHLEIN的其他文献

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{{ truncateString('YOSEF SCHLEIN', 18)}}的其他基金

PLANT DIETS OF SANDFLIES AND LEISHMANIA TRANSMISSION
白蛉和利什曼原虫传播的植物饮食
  • 批准号:
    2462157
  • 财政年份:
    1998
  • 资助金额:
    $ 10.63万
  • 项目类别:
PLANT DIETS OF SANDFLIES AND LEISHMANIA TRANSMISSION
白蛉和利什曼原虫传播的植物饮食
  • 批准号:
    6149830
  • 财政年份:
    1998
  • 资助金额:
    $ 10.63万
  • 项目类别:
PLANT DIETS OF SANDFLIES AND LEISHMANIA TRANSMISSION
白蛉和利什曼原虫传播的植物饮食
  • 批准号:
    2871553
  • 财政年份:
    1998
  • 资助金额:
    $ 10.63万
  • 项目类别:
TRANSMISSION OF LEISHMANIASIS
利什曼病的传播
  • 批准号:
    2298147
  • 财政年份:
    1994
  • 资助金额:
    $ 10.63万
  • 项目类别:
TRANSMISSION OF LEISHMANIASIS
利什曼病的传播
  • 批准号:
    2298148
  • 财政年份:
    1994
  • 资助金额:
    $ 10.63万
  • 项目类别:
TRANSMISSION OF LEISHMANIASIS
利什曼病的传播
  • 批准号:
    2298149
  • 财政年份:
    1994
  • 资助金额:
    $ 10.63万
  • 项目类别:
TRANSMISSION OF LEISHMANIASIS
利什曼病的传播
  • 批准号:
    2298146
  • 财政年份:
    1994
  • 资助金额:
    $ 10.63万
  • 项目类别:
ADAPTATION OF LEISHMANIA TO NATURAL DIETS OF THE VECTOR
利什曼原虫对媒介自然饮食的适应
  • 批准号:
    3147104
  • 财政年份:
    1992
  • 资助金额:
    $ 10.63万
  • 项目类别:
ADAPTATION OF LEISHMANIA TO NATURAL DIETS OF THE VECTOR
利什曼原虫对媒介自然饮食的适应
  • 批准号:
    2066975
  • 财政年份:
    1992
  • 资助金额:
    $ 10.63万
  • 项目类别:
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