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PLANT DIETS OF SANDFLIES AND LEISHMANIA TRANSMISSION

白蛉和利什曼原虫传播的植物饮食

基本信息

批准号：
6149830
负责人：
YOSEF SCHLEIN
金额：
$ 14.33万
依托单位：
HEBREW UNIVERSITY OF JERUSALEM
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-02-01 至 2002-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6149830
关键词：
Leishmania major Psychodidae communicable disease control dietary carbohydrates dietary constituent disease vectors enzyme linked immunosorbent assay epizootiology field study food chain insect control laboratory rabbit leishmaniasis plant extracts plants statistics /biometry systematic biology zoonosis

项目摘要

Abstract. Zoonotic Leishmania major causes human disease in similar arid regions in many countries including Israel. The general aim is to study the staple, plant-derived diets of the vector Phlebotomus papatasi and their effects on the vector competence of the sandflies in different habitats. The project comprises the following studies. Evaluation of the scarcity or abundance of plant-derived food sources in various study sites by the identification of plants on which the sandflies feed and by the relative quantities of sugars, or plant tissue residues in sandfly guts. Determination of the chronological age of sandflies from the same sites and the proportions of mature L. major infections they carry. The life span of sandflies is presumably shortened and the risk of human infection is decreased when rich food sources are not found in the local vegetation. The ingested tissues of some plant species, commonly fed upon by the sandflies (including Ricinus communis), kill and agglutinate L. major parasites in infected flies. Plants with this property among the species which are fed upon by sandflies in nature, will be identified; their prevalence in the different study sites will be assessed and their effects on the L. major infections in field caught flies will be scored. An extension of the above studies are the preliminary experiments aimed to assess the potential of using plants for the control of leishmaniasis. These include the selection of suitable domestic plant species and the spray of R. communis extract, which is expected to kill L. major parasites in sandflies, in the sprayed site.

抽象。人畜共患的利什曼原虫主要导致人类疾病，包括以色列在内的许多国家的干旱地区。总的目标是研究媒介白蛉的主食，植物来源的饮食 papatasi及其对白蛉媒介能力的影响在不同的栖息地。该项目包括以下研究。评估植物性食物来源的稀缺或丰富程度在不同的研究地点，通过确定植物上，白蛉的食物和相对数量的糖，或植物白蛉内脏中的组织残留物时间顺序的确定同一地点白蛉的年龄和成熟白蛉的比例。他们携带的严重感染。白蛉的寿命大概缩短和人类感染的风险降低时，丰富的食物在当地植被中没有发现污染源。摄入的组织一些植物物种，通常由白蛉喂养（包括蓖麻（Ricinus communis）对L.感染者中的主要寄生虫苍蝇具有这种特性的植物，自然界中白蛉，将被确定;它们在不同的研究地点将进行评估，其对L。将对现场捕获的苍蝇中的主要感染进行评分。延长上述研究是初步实验，旨在评估利用植物控制利什曼病的潜力。这些包括选择合适的国产植物品种，钢筋混凝communis提取物，预计将杀死L.主要寄生虫在白蛉中，在喷洒的地点。