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Achieving synaptic stability: An investigation of processes that maintain glutamate receptor clusters at synapses

实现突触稳定性：对突触维持谷氨酸受体簇的过程的研究

基本信息

批准号：
BB/J018724/1
负责人：
N Emptage
金额：
$ 44.06万
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2013
资助国家：
英国
起止时间：
2013 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FJ018724%2F1
关键词：
Achieving synaptic stability investigation processes

项目摘要

Memories, it is said can last a lifetime and yet the very molecules that form the substrate for memory are proteins that are highly labile and have a lifespan far shorter than the memory they represent. While one might imagine that if a molecule became damaged and was degraded by the cell, the solution would simply be to replace it with another molecule just like it, this is far from straight forward as the storage of a memory is thought to require these molecules to be arranged in precise patterns, with certain numbers of molecules at each point in the pattern. Thus, it is necessary to return the degraded molecule from whence it came. It would seem that what is needed is a memory for memory! As this is rather absurd then an alternative needs be sought. Ideally, a mechanism is required that self stabilizes once the memory is established. Importantly, any mechanism must have the capacity to show some adaptability, as memories are not always robust and can be augmented but can also wain. Recently, we have been exploring some theoretical ideas about the types of mechanism that might enable neurons to generate memories that become stable. Our ideas incorporate some less commonly considered features of biological processes and accept that the biological building blocks degrade and need to be replaced on a time scale far more rapid than the loss of memory. In our current work we are looking to test our theoretical ideas with experiments designed to determine whether stability arises from the behaviour of populations of molecules not the activity of any single element.

记忆，据说可以持续一生，但形成记忆基质的分子是高度不稳定的蛋白质，其寿命远远短于它们所代表的记忆。虽然人们可能会想象，如果一个分子被损坏并被细胞降解，解决方案将只是用另一个类似的分子取代它，但这远非直截了当，因为记忆的存储被认为需要这些分子以精确的模式排列，在模式中的每个点都有一定数量的分子。因此，有必要将降解的分子从其来源返回。看来，需要的是一个记忆的记忆！既然这是相当荒谬的，那么就需要寻找另一种选择。理想情况下，需要一种机制，一旦记忆建立，它就会自我稳定。重要的是，任何机制都必须有能力表现出一定的适应性，因为记忆并不总是强大的，可以增强，但也可以增强。最近，我们一直在探索一些关于神经元产生稳定记忆的机制类型的理论想法。我们的想法结合了一些不太常见的生物过程特征，并接受生物构建模块的退化，需要在一个比记忆丧失更快的时间尺度上进行替换。在我们目前的工作中，我们希望通过实验来测试我们的理论想法，这些实验旨在确定稳定性是否来自分子群体的行为，而不是任何单一元素的活动。