Smart Materials for Wound Healing: A New Fast Acting in situ Method to Treat Skin and Eye wounds

用于伤口愈合的智能材料：一种治疗皮肤和眼睛伤口的新型快速原位方法

• 批准号: BB/J019836/1
• 负责人: Ian Hamley
• 金额: $ 15.6万
• 依托单位: University of Reading
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FJ019836%2F1
• 关键词: Smart; Materials; Wound; Healing; New

We will develop a new type of smart functionalized biomaterial for use in wound healing with applications in the defence sector. The system will incorporate multiple functionalities to stimulate the production of new tissue and degradation of scar tissue, via incorporation of different peptide units. These will be cross-linked by UV radiation to form a fibrillar scaffold. The UV cross-linking can be performed in situ locally following topical application of a spray or cream. The system will act as a rigid "filler" scaffold for tissue regrowth. This approach is different to existing techniques. This technology is highly suited for the treatment of battlefield wounds in situ, as well as the treatment of burns and post-operative wounds. It will be developed to treat wounds to the skin as well as the cornea. The technology is expected to be fast acting and is based on ease of end-use application.

我们将开发一种用于伤口愈合的新型智能功能化生物材料，并将其应用于国防领域。该系统将结合多种功能，通过结合不同的肽单元来刺激新组织的产生和疤痕组织的降解。它们将在紫外线辐射下交联，形成纤维支架。紫外线交联可以在局部使用喷雾或面霜后就地进行。该系统将作为组织再生的刚性“填充”支架。这种方法不同于现有的技术。这项技术非常适合战场伤口的原位治疗，以及烧伤和术后伤口的治疗。它将被开发用于治疗皮肤和角膜的伤口。该技术有望快速发挥作用，并基于易于最终使用的应用。

项目成果

Self-assembly of a dual functional bioactive peptide amphiphile incorporating both matrix metalloprotease substrate and cell adhesion motifs.

• DOI: 10.1039/c5sm00459d
• 发表时间: 2015-04
• 期刊: Soft matter
• 影响因子: 3.4
• 作者: A. Dehsorkhi;R. Gouveia;Andrew M. Smith;I. Hamley;V. Castelletto;C. Connon;M. Reza;J. Ruokolainen