权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Nanostructured Polymeric Materials for Healthcare

用于医疗保健的纳米结构高分子材料

基本信息

批准号：
EP/L020599/1
负责人：
Ian Hamley
金额：
$ 151.1万
依托单位：
University of Reading
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2014
资助国家：
英国
起止时间：
2014 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FL020599%2F1
关键词：
Nanostructured Polymeric Materials Healthcare

项目摘要

Key scientific/technological challenges facing mankind in the opening decades of the 21st Century include those associated with improved healthcare. A global challenge results from the worldwide improvement in life expectancy, which is leading to an urgent need for new biomedical materials, to facilitate regenerative medicine. This involves using bio-derived or biologically inspired materials to regenerate tissue or even ultimately organs. In particular, our research involves the creation of new materials for tissue engineering of the cornea and skin, based around functionalized peptide/polymer water-based gels. We are developing materials that can repair collagen or stimulate its production, leading to new ways to treat eye and flesh wounds. We will also extend and develop our ongoing research programme on neurodegenerative diseases such as Alzheimer's disease, which affects millions of people around the world. We are developing novel diagnostic and potentially therapeutic systems based on preventing the aggregation of proteins that is believed to be the cause of this and related diseases such as CJD and type II diabetes.Population growth and economic development across the planet is leading to rapidly increasing demands for clean drinking water, with even the prospect of "water wars" between nations which are constrained to share water resources. Here, membrane science is key to meeting the challenge, with our own work focusing on the the development of membranes for the recycling of drinking water by low-pressure nanofiltration and ultrafiltration techniques. The performance characteristics of polymeric materials are often crucially dependent on their detailed structure at the nanoscale. A fundamental aim of our research is to achieve specified polymer nanostructures through the self-assembly of polymer chains, with the assembly process itself being governed by the chain-sequences of the polymers involved. Synthetic methods providing unprecedented control over monomer sequences will be developed in the new research made possible by the Platform grant. This design-approach, underpinned by insights resulting from high-level theoretical studies and state-of-the-art structural analyses, will be followed in nearly all our work - from the study of membrane ionomers and amyloid-forming copolymers to new, exploratory work on self-repairing polymers and on polymer brushes as potentially responsive and biocompatible surfaces.The Reading Polymer Group (I.W. Hamley, H.M. Colquhoun, C.J. Connon, W. Hayes and Z. Wang) is involved in numerous international collaborations. The Group's areas of expertise, in polymer design and synthesis (Colquhoun, Hayes and Hamley), characterisation (Hamley), biomaterials development (Connon and Hamley) and modelling (Wang) are highly complementary. The Group is funded from a wide range of sources and currently holds grants and external studentship-funding to a total value of £8M, including ca. £4M of RCUK funding (primarily EPSRC and BBSRC).

人类在21世纪世纪开始的几十年中面临的关键科学/技术挑战包括与改善医疗保健相关的挑战。世界范围内预期寿命的提高带来了一个全球性挑战，这导致迫切需要新的生物医学材料来促进再生医学。这涉及使用生物衍生或生物启发的材料来再生组织或甚至最终器官。特别是，我们的研究涉及创建角膜和皮肤组织工程的新材料，基于功能化肽/聚合物水基凝胶。我们正在开发可以修复胶原蛋白或刺激其产生的材料，从而为治疗眼睛和皮肤伤口提供新的方法。我们还将扩大和发展我们正在进行的关于神经退行性疾病的研究方案，如影响世界各地数百万人的阿尔茨海默病。我们正在开发新的诊断和潜在的治疗系统的基础上，防止蛋白质的聚集，这被认为是导致这种疾病和相关疾病，如CJD和II型糖尿病。全球人口增长和经济发展导致对清洁饮用水的需求迅速增加，甚至有前景的“水战争”之间的国家之间的限制，以分享水资源。在这里，膜科学是迎接挑战的关键，我们自己的工作重点是通过低压纳滤和超滤技术开发用于饮用水循环的膜。聚合物材料的性能特征通常关键地取决于它们在纳米级的详细结构。我们研究的一个基本目标是通过聚合物链的自组装实现特定的聚合物纳米结构，组装过程本身由所涉及的聚合物的链序列控制。在平台资助的新研究中，将开发对单体序列提供前所未有的控制的合成方法。这种设计方法以高水平的理论研究和最先进的结构分析为基础，将在我们几乎所有的工作中得到遵循-从膜离聚物和淀粉样蛋白形成共聚物的研究到自修复聚合物和聚合物刷作为潜在的响应和生物相容性表面的新的探索性工作。Hamley，H.M. Colquhoun，C.J. Connon，W. Hayes和Z. Wang）参与了许多国际合作。该集团在聚合物设计和合成（Colquhoun、Hayes和Hamley）、表征（Hamley）、生物材料开发（Connon和Hamley）和建模（Wang）等专业领域具有高度互补性。该集团的资金来自广泛的来源，目前持有赠款和外部学生资助，总价值为800万英镑，其中包括约1000万英镑。400万英镑的RCUK资金（主要是EPSRC和BBSRC）。