Amyloid Peptide Conjugates: Visit to Argentina to Develop Collaboration

我们建议启动一项合作计划，以检查肽/聚合物缀合物对体外和体内淀粉样蛋白fiflisation的影响。预期缀合物结合淀粉样蛋白并破坏纤维化。阅读团队成员将访问Instituto Leloir（阿根廷布宜诺斯艾利斯），进行细胞活力/细胞毒性实验。Leloir研究所由诺贝尔奖获得者Luis Federico Leloir创立，是南美洲致力于生物化学的主要机构之一，事实上，它具有领先的国际形象。Leloir团队的成员将参观阅读的X射线，中子和电子显微镜实验。老年痴呆症和II型糖尿病等疾病对发达国家的老龄化人口越来越重要。它们是由淀粉样蛋白的形成引起的，其中蛋白质和肽形成基于β-折叠结构的原纤维，其中肽骨架与原纤维轴正交（交叉β结构）。我们建议启动一项合作计划，以检查肽/聚合物缀合物对体外和体内淀粉样蛋白fiflisation的影响。预期缀合物结合淀粉样蛋白并以刺激响应的方式破坏纤维化。人类淀粉样肽Abeta与阿尔茨海默病有关。

We propose to initiate a collaborative programme to examine the effect of peptide/polymer conjugates on amyloid fibrillisation in vitro and in vivo. The conjugates are expected to bind to amyloid and to disrupt fibrillisation. Members of the Reading team will visit Instituto Leloir (Buenos Aires, Argentina) to perform cell viability/cytotoxicity experiments. The Instituto Leloir was founded by the Nobel laureate Luis Federico Leloir and is one of the premier institutions devoted to biochemistry in South America, indeed it has a leading international profile. Members of the Leloir team will visit Reading for x-ray, neutron and electron microscopy experiments. Diseases such as Alzheimer's and type II diabetes are of increasing importance to the aging population in the developed world. They result result from the formation of amyloid in which proteins and peptides form fibrils based on a beta-sheet structure in which the peptide backbone is orthogonal to the fibril axis (cross beta structure). We propose to initiate a collaborative programme to examine the effect of peptide/polymer conjugates on amyloid fibrillisation in vitro and in vivo. The conjugates are expected to bind to amyloid and to disrupt fibrillisation in a stimuli-responsive fashion. The human amyloid peptide, Abeta is implicated in Alzheimers.