RADIONUCLIDE ADRENAL IMAGING IN HYPERTENSION

高血压的放射性核素肾上腺成像

• 批准号: 3151377
• 负责人: JAMES C SISSON
• 金额: $ 19万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-09-01 至 1987-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3151377
• 关键词: Cushing's syndrome; adrenal glands; adrenal hypertension; aldosterone; angiogenesis; angiotensin /renin /aldosterone hypertension; antibody formation; cholesterol; corticosteroids; dopamine beta monooxygenase; drug design /synthesis /production; endocrine disorder diagnosis; human subject; image processing; neuroblastoma; radionuclide diagnosis; radiopharmacology; radiotracer; renin

The objectives of this proposed work are three-fold: 1. To corroborate in a larger prospective study our presently completed feasibility study in 45 patients. This study illustrates that dexamethasone suppression adrenal scintiscanning with radioiodinated cholesterol reveals 4 anatomical-functional imaging patterns in patients with low renin essential hypertension: 1. Uptake of I-131 in one adrenal only is found in an adenoma of one adrenal cortex. 2. Symmetrical uptake early and late is found in macronodular hyperplasia of the adrenal cortex. 3. Symmetrical uptake four days or more after tracer administration is found in micronodular hyperplasia. 4. No uptake in either adrenal early or late is found when the adrenal cortices are normal. Blood pressure falls to normal during the administration of spironolactone when the adrenal cortex is abnormal as recognized by scintiscanning but does not respond significantly to spironolactone when the adrenal cortex is normal. 2. To synthesize, develop and evaluate radiolabeled inhibitors of enzymes in adrenal glands would decrease the time required for imaging and the radiation dose in comparison to the currently used radioiodinated cholesterols. 3. To synthesize, develop and evaluate the anatomical-functional imaging capabilities of radiolabeled neuronal blocking agents, and reversible inhibitors of enzymes in the adrenal medulla. The diagnostic capabilities of the most successful of these radiolabeled imaging agents will be analyzed first in patients most at risk for disease of the adrenal medulla, then in patients with normal and high renin hypertension.

这项拟议工作的目标有三个方面：1。来证实 我们目前已完成的可行性研究， 患者 这项研究表明，地塞米松抑制肾上腺皮质激素， 放射性碘标记胆固醇扫描显示4个解剖功能 低肾素原发性高血压患者的影像学表现：1.摄取 仅在一侧肾上腺皮质腺瘤中发现一个肾上腺中的I-131。 2. 在大结节增生中发现了早期和晚期的对称性摄取， 肾上腺皮质3.示踪剂后4天或更长时间对称摄取 在微小结节增生中发现了给药。 4.两种都没有摄取 当肾上腺皮质正常时，发现肾上腺早期或晚期。 血液 在螺内酯给药期间， 肾上腺皮质是异常的，如通过磁共振扫描所识别的，但不响应 当肾上腺皮质正常时，对螺内酯有显著影响。 2.到 放射性标记肾上腺酶抑制剂的合成、开发和评价 腺体将减少成像所需的时间和辐射剂量， 与目前使用的放射性碘化胆固醇相比。 3.为了合成， 开发和评估解剖功能成像能力， 放射性标记的神经元阻断剂和可逆的酶抑制剂， 肾上腺髓质 世界上最成功的 这些放射性标记的显像剂将首先在患者中进行分析， 肾上腺髓质疾病的风险，那么在正常和高 高血压

项目成果

The location of middle mediastinal pheochromocytomas.

中纵隔嗜铬细胞瘤的位置。

• 发表时间: 1984
• 期刊: The Journal of thoracic and cardiovascular surgery
• 作者: Shapiro,B;Sisson,J;Kalff,V;Glowniak,J;Satterlee,W;Glazer,G;Francis,I;Bowers,R;Thompson,N;Orringer,M
• 通讯作者: Orringer,M

Adrenal cortical 11 beta-hydroxylase and side-chain cleavage enzymes. Requirement for the A- or B-pyridyl ring in metyrapone for inhibition.

肾上腺皮质 11 β-羟化酶和侧链裂解酶。

• DOI: 10.1016/0022-4731(85)90148-7
• 发表时间: 1985
• 期刊: Journal of steroid biochemistry
• 作者: Tobes,MC;Hays,SJ;Gildersleeve,DL;Wieland,DM;Beierwaltes,WH
• 通讯作者: Beierwaltes,WH

The normal and abnormal distribution of the adrenomedullary imaging agent m-[I-131]iodobenzylguanidine (I-131 MIBG) in man: evaluation by scintigraphy.

肾上腺髓质显像剂 m-[I-131] 碘苄基胍 (I-131 MIBG) 在人体中的正常和异常分布：通过闪烁扫描进行评估。

• 发表时间: 1983
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Nakajo,M;Shapiro,B;Copp,J;Kalff,V;Gross,MD;Sisson,JC;Beierwaltes,WH
• 通讯作者: Beierwaltes,WH

The Spectrum of Pheochromocytoma in Hypertensive Patients with Neurofibromatosis

高血压合并神经纤维瘤病患者的嗜铬细胞瘤谱

• 发表时间: 1983
• 作者: V. Kalff;B. Shapiro;R. Lloyd;J. Sisson;K. Holland;M. Nakajo;W. Beierwaltes
• 通讯作者: W. Beierwaltes

Scintigraphic approach to the localization of adrenal lesions causing hypertension.

闪烁扫描法定位引起高血压的肾上腺病变。

• DOI: 10.1007/bf02938810
• 发表时间: 1981
• 期刊: Urologic radiology
• 作者: Gross,MD;Thompson,NW;Beierwaltes,WH
• 通讯作者: Beierwaltes,WH