DIETARY FAT, CARBOHYDRATE BALANCE & WEIGHT MAINTENANCE
DIETARY FAT, CARBOHYDRATE BALANCE & WEIGHT MAINTENANCE
批准号:
3152743
负责人:
JEAN-PIERRE FLATT
金额:
$11.56万
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-07-01 至 1986-06-30
关键词:
blood chemistry blood glucose calorimetry carbohydrate metabolism dietary carbohydrates dietary lipid fat body fatty acid metabolism free fatty acids glycogen glycogenesis glycogenolysis insulin ketone body mass spectrometry nutrient intake activity nutrition related tag obesity oxidation reduction reaction oxygen consumption radioimmunoassay respiratory gas analyzer triglycerides weight control
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Glycogen stores may fluctuate around rather low or rather high average
levels, as part of the metabolic adaptation permitting carbohydrate
oxidation to be commensurate with the diets corbohydrate contents. The
hypothesis which will be tested is that an expansion or reduction of the
adipose tissue mass also represents and adaptation, influencing free-fatty
acid levels until fat oxidation becomes commensurate, percentage-wise, with
a particular diet's fat content. Long-term weight maintenance would then
be achieved thanks to the ubiquitous ability for maintaining carbohydrate
balance by mutual adjustment of food intake to carbohydrate oxidation and
vice-versa. But whereas changes in the glycogen stores hardly affect body
weight;, alterations of the adipose tissue mass can lead to obesity.
Herein could be found a simple explanation for the high incidence of
obesity in affluent societies consuming "mixed" diets with a relatively
high-fat content.
The relationship between the fat content of the diet and the steady-state
adipose tissue mass will be studied by carcass analysis of mice adapted to
diets with a fixed protein, but variable carbohydrate and fat contents (12
to 83 percent calories as fat). The experiments will be designed to reveal
whether this relationship is progressive and reversible, which would
confirm the adaptive nature of diet-induced changes in adiposity. Some
animals will be kept in hermetically sealed chambers, vented once every 24
hours, to measure their O2 consumption and CO2 production. In conjunction
with measurements of nutrient intake (corrected for spillage and incomplete
absorption) this will allow to calculate daily changes in the animals'
carbohydrate and fat contents. Such data will allow to determine how
accurately the carbohydrate, fat and energy balances are maintained under
ad libitum food intake conditions, and to examine whether and how food
intake may be altered in response to gains, or losses in the animal's
glycogen and/or fat reserves.
The general goal of the proposed investigations is to demonstrate the
impact of the dietary fat content on steady-state body composition.
Ultimately this may allow to develop metabolic arguments (in addition to
those based on caloric density) suggesting that a reduction in the
diets'fat content may facilitate weight maintenance at a lower level of
adiposity.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
COMPUTER MODEL OF HUMAN SUBSTRATE METABOLISM
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批准号:6369874
-
项目类别:
-
资助金额:$7.85万
-
财政年份:2000
-
负责人:JEAN-PIERRE FLATT
-
依托单位:
COMPUTER MODEL OF HUMAN SUBSTRATE METABOLISM
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批准号:6033253
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项目类别:
-
资助金额:$6.52万
-
财政年份:2000
-
负责人:JEAN-PIERRE FLATT
-
依托单位:
COMPUTER MODEL OF HUMAN SUBSTRATE METABOLISM
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批准号:6517687
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项目类别:
-
资助金额:$3.98万
-
财政年份:2000
-
负责人:JEAN-PIERRE FLATT
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依托单位:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
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批准号:2138991
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项目类别:
-
资助金额:$19.83万
-
财政年份:1984
-
负责人:JEAN-PIERRE FLATT
-
依托单位:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
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批准号:3231589
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项目类别:
-
资助金额:$11.94万
-
财政年份:1984
-
负责人:JEAN-PIERRE FLATT
-
依托单位:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
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批准号:3231594
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项目类别:
-
资助金额:$13.14万
-
财政年份:1984
-
负责人:JEAN-PIERRE FLATT
-
依托单位:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
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批准号:3231592
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项目类别:
-
资助金额:$19.16万
-
财政年份:1984
-
负责人:JEAN-PIERRE FLATT
-
依托单位:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
-
批准号:3231593
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项目类别:
-
资助金额:$12.56万
-
财政年份:1984
-
负责人:JEAN-PIERRE FLATT
-
依托单位:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
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批准号:3231595
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项目类别:
-
资助金额:$18.96万
-
财政年份:1984
-
负责人:JEAN-PIERRE FLATT
-
依托单位:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
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批准号:3231590
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项目类别:
-
资助金额:$20.71万
-
财政年份:1984
-
负责人:JEAN-PIERRE FLATT
-
依托单位:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
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批准号:2458738
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项目类别:
-
资助金额:$22.03万
-
财政年份:1984
-
负责人:JEAN-PIERRE FLATT
-
依托单位:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
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批准号:2138993
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项目类别:
-
资助金额:$21.18万
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财政年份:1984
-
负责人:JEAN-PIERRE FLATT
-
依托单位:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
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批准号:2138992
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项目类别:
-
资助金额:$20.63万
-
财政年份:1984
-
负责人:JEAN-PIERRE FLATT
-
依托单位:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
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批准号:3231596
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项目类别:
-
资助金额:$18.36万
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财政年份:1984
-
负责人:JEAN-PIERRE FLATT
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依托单位:
海外基金