DIETARY FAT, CARBOHYDRATE BALANCE & WEIGHT MAINTENANCE
膳食脂肪、碳水化合物平衡
基本信息
- 批准号:3152743
- 负责人:
- 金额:$ 11.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1984
- 资助国家:美国
- 起止时间:1984-07-01 至 1986-06-30
- 项目状态:已结题
- 来源:
- 关键词:blood chemistry blood glucose calorimetry carbohydrate metabolism dietary carbohydrates dietary lipid fat body fatty acid metabolism free fatty acids glycogen glycogenesis glycogenolysis insulin ketone body mass spectrometry nutrient intake activity nutrition related tag obesity oxidation reduction reaction oxygen consumption radioimmunoassay respiratory gas analyzer triglycerides weight control
项目摘要
Glycogen stores may fluctuate around rather low or rather high average
levels, as part of the metabolic adaptation permitting carbohydrate
oxidation to be commensurate with the diets corbohydrate contents. The
hypothesis which will be tested is that an expansion or reduction of the
adipose tissue mass also represents and adaptation, influencing free-fatty
acid levels until fat oxidation becomes commensurate, percentage-wise, with
a particular diet's fat content. Long-term weight maintenance would then
be achieved thanks to the ubiquitous ability for maintaining carbohydrate
balance by mutual adjustment of food intake to carbohydrate oxidation and
vice-versa. But whereas changes in the glycogen stores hardly affect body
weight;, alterations of the adipose tissue mass can lead to obesity.
Herein could be found a simple explanation for the high incidence of
obesity in affluent societies consuming "mixed" diets with a relatively
high-fat content.
The relationship between the fat content of the diet and the steady-state
adipose tissue mass will be studied by carcass analysis of mice adapted to
diets with a fixed protein, but variable carbohydrate and fat contents (12
to 83 percent calories as fat). The experiments will be designed to reveal
whether this relationship is progressive and reversible, which would
confirm the adaptive nature of diet-induced changes in adiposity. Some
animals will be kept in hermetically sealed chambers, vented once every 24
hours, to measure their O2 consumption and CO2 production. In conjunction
with measurements of nutrient intake (corrected for spillage and incomplete
absorption) this will allow to calculate daily changes in the animals'
carbohydrate and fat contents. Such data will allow to determine how
accurately the carbohydrate, fat and energy balances are maintained under
ad libitum food intake conditions, and to examine whether and how food
intake may be altered in response to gains, or losses in the animal's
glycogen and/or fat reserves.
The general goal of the proposed investigations is to demonstrate the
impact of the dietary fat content on steady-state body composition.
Ultimately this may allow to develop metabolic arguments (in addition to
those based on caloric density) suggesting that a reduction in the
diets'fat content may facilitate weight maintenance at a lower level of
adiposity.
糖原储备可能在相当低或相当高的平均值上下波动
水平,作为代谢适应的一部分,
氧化与饮食碳水化合物含量相称。 的
将被检验的假设是,
脂肪组织质量也代表和适应,影响游离脂肪
酸水平,直到脂肪氧化变得相称,明智的,
特定饮食的脂肪含量 长期保持体重,
这要归功于维持碳水化合物的普遍能力,
通过相互调节食物摄入量来平衡碳水化合物氧化,
反之亦然。 但是,尽管糖原储存的变化几乎不影响身体
体重增加,脂肪组织质量的改变可导致肥胖。
这里可以找到一个简单的解释高发病率
肥胖在富裕社会消费“混合”饮食与相对
高脂肪含量。
饲料中脂肪含量与稳态的关系
将通过对适应于以下的小鼠的尸体分析来研究脂肪组织质量:
蛋白质含量固定,但碳水化合物和脂肪含量可变的饮食(12
83%的卡路里作为脂肪)。 这些实验旨在揭示
这种关系是否是渐进的和可逆的,
证实了饮食引起的肥胖变化的适应性。 一些
动物将被关在密封的房间里,每24小时通风一次。
小时,以测量其O2消耗和CO2产生。 结合
营养摄入量的测量(对溢出和不完整的
吸收),这将允许计算动物的
碳水化合物和脂肪含量。 这些数据将有助于确定
准确地说,碳水化合物、脂肪和能量平衡是在
随意进食的条件,并检查是否和如何食物
摄入量可能会随着动物体重的增加或减少而改变。
糖原和/或脂肪储备。
拟议调查的总体目标是证明
膳食脂肪含量对稳态身体组成的影响。
最终,这可能允许发展代谢论点(除了
那些基于热量密度),这表明,
饮食中的脂肪含量可能有助于将体重维持在较低的水平,
肥胖症
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JEAN-PIERRE FLATT其他文献
JEAN-PIERRE FLATT的其他文献
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{{ truncateString('JEAN-PIERRE FLATT', 18)}}的其他基金
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
膳食脂肪、碳水化合物平衡和体重维持
- 批准号:
2138991 - 财政年份:1984
- 资助金额:
$ 11.56万 - 项目类别:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
膳食脂肪、碳水化合物平衡和体重维持
- 批准号:
3231589 - 财政年份:1984
- 资助金额:
$ 11.56万 - 项目类别:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
膳食脂肪、碳水化合物平衡和体重维持
- 批准号:
3231594 - 财政年份:1984
- 资助金额:
$ 11.56万 - 项目类别:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
膳食脂肪、碳水化合物平衡和体重维持
- 批准号:
3231592 - 财政年份:1984
- 资助金额:
$ 11.56万 - 项目类别:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
膳食脂肪、碳水化合物平衡和体重维持
- 批准号:
3231593 - 财政年份:1984
- 资助金额:
$ 11.56万 - 项目类别:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
膳食脂肪、碳水化合物平衡和体重维持
- 批准号:
3231595 - 财政年份:1984
- 资助金额:
$ 11.56万 - 项目类别:
DIETARY FAT, CARBOHYDRATE BALANCE AND WEIGHT MAINTENANCE
膳食脂肪、碳水化合物平衡和体重维持
- 批准号:
3231590 - 财政年份:1984
- 资助金额:
$ 11.56万 - 项目类别:
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