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Keeping track of things: Forming associations between temporally separated events

跟踪事物：在时间上分离的事件之间形成关联

基本信息

批准号：
BB/K004980/1
负责人：
Helen Cassaday
金额：
$ 53.21万
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2013
资助国家：
英国
起止时间：
2013 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FK004980%2F1
关键词：
Keeping track things Forming associations

项目摘要

When there is a time gap between events, we are less able to make a connection between them in learning and later memory. Thus it is harder to keep track of things that could in fact be causally related, in order - for example - to know that even distant engine noise can predict a future hazard or to anticipate dinner based on the smell of raw ingredients. The ability successfully to bridge a time gap between events is known to deteriorate with age. This project will investigate the underpinning brain substrates of this important cognitive ability in relation to its psychological bases. One possibility is that the mental image of the first event fades before the association at issue can be made. An alternative possibility is that other intervening events interfere with the association between the first event and the outcome event. The differential role of time versus interference will be examined in experiments which systematically compare how learning is reduced by a time gap between the end of the first event and the start of the outcome event, relative to the reduction in learning produced by events of extended duration which do not terminate before the start of the outcome event (such that the overall time duration to be bridged is equivalent). In the first scenario the potential for competing events to interfere with conditioning is much greater. These experiments will be conducted on rats using highly controlled presentation of events such as a distinctive noise followed by a mild foot shock. Because the 'events' presented in such controlled experimental studies are somewhat artificial (e.g., a pure tone stimulus) we will also test the effects of the same interventions in the brain on the recognition of three-dimensional objects. In a complementary series of experiments we will present the objects with and without a time delay before familiarity is tested, with and without the presentation of intervening objects.The brain interventions will be precisely targeted in both cortical and sub-cortical areas implicated in these processes. The present project will advance on previous findings in that we will selectively interfere with chemical signalling within these pathways, both by depleting brain chemicals in specific pathways and by targeted drug delivery.In parallel with the experimental programme, we will visit schools and use sixth form outreach programmes to explain the importance of animal work of this kind. Once we have identified the psychological bases of deficits produced by depletion within a pathway, we will engage with contacts in the pharmaceutical industry to ensure that we follow-up on the most important findings with the most appropriate drug tests.

当事件之间存在时间间隔时，我们在学习和后来的记忆中就不太能够将它们联系起来。因此，很难跟踪实际上可能存在因果关系的事情，例如，为了知道即使是遥远的发动机噪音也可以预测未来的危险，或者根据原料的气味预测晚餐。人们知道，随着年龄的增长，成功地弥合事件之间的时间差距的能力会下降。这个项目将研究这种重要的认知能力的基础大脑基板与其心理基础的关系。一种可能性是，第一个事件的心理形象在产生有争议的联想之前就消失了。另一种可能性是其他介入事件干扰第一事件和结果事件之间的关联。时间与干扰的不同作用将在实验中进行研究，这些实验系统地比较了学习如何被第一个事件结束和结果事件开始之间的时间间隔所减少，相对于由持续时间延长的事件产生的学习减少，这些事件在结果事件开始之前没有终止（这样要桥接的总持续时间是相等的）。在第一种情况下，竞争事件干扰条件反射的可能性要大得多。这些实验将在大鼠身上进行，使用高度受控的事件呈现，例如独特的噪音，然后是轻微的足部电击。因为在这种对照实验研究中呈现的“事件”有些人为（例如，纯音刺激），我们还将测试同样的干预对大脑识别三维物体的影响。在一系列补充实验中，我们将在测试熟悉度之前，在有和没有时间延迟的情况下呈现物体，在有和没有介入物体的情况下呈现物体，大脑干预将精确地针对与这些过程有关的皮层和皮层下区域。本研究计划将在以往研究的基础上更进一步，我们会选择性地干扰这些通路中的化学信号，方法包括消耗特定通路中的大脑化学物质，以及有针对性地投放药物。在进行实验计划的同时，我们会探访学校，并利用中六外展计划，解释这类动物工作的重要性。一旦我们确定了在一个途径中由消耗产生的缺陷的心理基础，我们将与制药行业的联系人接触，以确保我们通过最适当的药物测试来跟踪最重要的发现。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Handbook of Research on Object Novelty Recognition. Handbook of Behavioral Neurosciences

物体新颖性识别研究手册。

DOI：
发表时间：
2018
期刊：
影响因子：
0
作者：
Cassaday, H.J.
通讯作者：
Cassaday, H.J.

Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat.

DOI：
10.1177/0269881120965914
发表时间：
2020-12
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
0
作者：
Pezze MA;Marshall HJ;Cassaday HJ
通讯作者：
Cassaday HJ

Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure.

DOI：
10.1002/brb3.1147
发表时间：
2018-12
期刊：
Brain and behavior
影响因子：
3.1
作者：
Pezze MA;Marshall HJ;Cassaday HJ
通讯作者：
Cassaday HJ

Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: Role of the prelimbic cortex.

DOI：
10.1016/j.euroneuro.2015.07.018
发表时间：
2015-11
期刊：
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
影响因子：
0
作者：
Pezze MA;Marshall HJ;Fone KC;Cassaday HJ
通讯作者：
Cassaday HJ

From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations.