课题基金 / 基金详情

MOLECULAR MECHANISMS IN NEOPLASIA

MOLECULAR MECHANISMS IN NEOPLASIA
肿瘤的分子机制
批准号：
3165229
负责人：
PAUL Eric NEIMAN
金额：
$14.02万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
1976
资助国家：
美国
项目状态：
已结题
起止时间：
1976-03-01 至 1986-02-28
来源：
https://reporter.nih.gov/project-details/3165229
关键词：
alleles alpharetrovirus animal age group bursa of Fabricius clone cells gene expression genetic manipulation genetic recombination genome lymphoma molecular cloning molecular oncology neoplasm /cancer classification /staging neoplasm /cancer genetics nucleic acid sequence oncogenic virus provirus transforming virus viral leukemogenesis virus genetics

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英文摘要
This project deals with molecular mechanisms underlying Avian Leukosis Virus (ALV) induced neoplasms including bursal lymphomas in chickens. The integrated exogenous provirus of ALV and adjacent host sequences in clonal neoplasms will be cloned in prokaryotic vectors using recombinant DNA technology and detailed studies of the structure and function of these sequences will be carried out. Evidence of recombination with host cell sequences will be sought and integration site of ALV provirus in different normal and neoplastic tissues will be compared. The sequences in cellular DNA preparation from ALV induced neoplasms which transform NIH/3T3 mouse cells in transfection experiments will be characterized with respect to known putative transforming genes in chicken cells and an attempt made to isolate these sequences by molecular cloning techniques. The genetic elements of ALV responsible for its oncongenic properties will be identified by biochemical substitution of allelic segments of a non-oncogenic endogenous avian retrovirus.
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