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PROGRAM IN RETROVIRUSES AND CANCER

PROGRAM IN RETROVIRUSES AND CANCER
逆转录病毒和癌症项目
批准号：
3093218
负责人：
PAUL Eric NEIMAN
金额：
$55.88万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
1980
资助国家：
美国
项目状态：
已结题
起止时间：
1980-07-01 至 1986-09-29
来源：
https://reporter.nih.gov/project-details/3093218
关键词：
Retroviridae oncogenic virus viral leukemogenesis virus genetics

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中文摘要
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英文摘要
This grant is concerned with the role of retroviruses in malignant transformation of host cells. Individual projects will address the characterization of integrated leukemia virus genomes and of endogenous host cell sequences (endogenous onc) related to the transforming genes of avian acute leukemia viruses. The characterization of viral RNA and protein gene products as well as a biological characterization of released viruses in both murine leukemia virus-induced thymomas and avian leukemia virus-induced bursal lymphomas. Methods will include molecular cloning of viral and host cell sequences and the use of hybridomas to generate monoclonal antibodies. The latter will be used in studies of both viral and host nuclear proteins.
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会议论文
Genomic Analysis of Gene Copy Number in Thyroid Cancer
Workshop On Experimental Models from Bursa of Fabricius
MOLECULAR CLONING OF C-MYC TRANSCRIPTION FACTOR GENES
GENES REGULATING APOPTOTIC CELL DEATH IN BURSAL B-CELLS
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