CANCER EPIDEMIOLOGY OF THE MIGRANT JAPANESE IN HAWAII

这是一项针对8006名日本血统男性的前瞻性研究， 出生于1900年至1919年，他们从 1965至1968年。大量基于流行病学的数据是 收集了这些人的信息，他们一直在 自检查以来，医院一直在监测癌症。通过 1988年9月，即建议续期日期5- 年提案，预计将有1289例癌症 在研究人群中诊断的事件病例：215个前列腺， 肺癌202例，胃癌190例，结肠癌188例，直肠癌101例 其他。我们计划与这组人一起研究以下几点：1) 血清尿酸，一种抗氧化剂，通过 具体类型；2)进一步观察血清与 胆固醇与结肠癌；3)膀胱癌的关系 癌症(基于90个事故案例)与吸烟有关， 咖啡、酒精和饮食中维生素A和C的摄入量；4) 肺功能测量与肺癌风险的关系； 5)体力活动与癌症风险的关联，尤其是 结肠癌；6)流行病学危险因素的识别 在死者身上偶然发现的隐匿性前列腺癌 在队列中已收到协议尸检的人；以及7) 隐匿性甲状腺疾病流行病学危险因素识别 在死亡者身上偶然发现的癌症。在这两个人中 基于尸检的研究，患有隐匿性癌症的受试者将 与未患隐匿性癌症的受试者相比 病理学家做的常规尸检。 除了这七个目标外，还有另外三个目标。 1971年至1975年，6860名受试者(占最初8006名男性的85.7%) 进行复查并采集血清样本。有了这个 资源，嵌套病例对照研究将使用预 诊断血清确定以下内容：8)与 血清胡萝卜素和生育酚组分与鳞癌的关系 (包括口腔癌、下咽癌、食道癌、 喉、肺)；以及9)某些血清痕量的关联 元素(铁、锌、铜)与癌症的具体类型。 最后，还对原始研究对象进行了30%的系统抽样 1970年至1972年被选中复查，当时 空腹血浆甘油三酯和脂蛋白组分 量过了。血浆甘油三酯与高、低水平的关系 和极低密度脂蛋白在特定部位有致癌风险 将在这个2095名男性的子样本中进行研究。

This is a prospective study of 8006 men of Japanese ancestry, born from 1900 to 1919, who were questioned and examined from 1965 to 1968. A wealth of epidemiologic-based data was collected on these men, and they have been under continuous hospital surveillance for cancer since their examination. By September, 1988, which is the proposed renewal date for this 5- year proposal, it is estimated that there will be 1289 cancer incident cases diagnosed in the study population: 215 prostate, 202 lung, 190 stomach, 188 colon and 101 rectal cancers, among others. We plan to study the following with this cohort: 1) the association of serum uric acid, an antioxidant, with cancer by specific type; 2) a further look at the relation of serum cholesterol to colon cancer; 3) the association of urinary bladder cancer (based on 90 incident cases) with cigarette smoking, coffee, alcohol, and the intake of dietary vitamin A and C; 4) the relation of pulmonary function measurements to lung cancer risk; 5) the association of physical activity with cancer risk, especially colon cancer; 6) the identification of epidemiologic risk factors for occult prostate cancer found incidentally in deceased subjects in the cohort who have received protocol autopsies; and 7) the identification of epidemiologic risk factors for occult thyroid cancer found incidentally in deceased subjects. In these two autopsy-based studies, subjects with occult cancer will be compared with subjects without occult cancer who have received protocol autopsies done by the pathologist. In addition to these seven objectives, there are three others. From 1971 to 1975, 6860 subjects (85.7% of the original 8006 men) were re-examined and serum samples were collected. With this resource, nested case-control studies will be done using pre- diagnostic serum to determine the following: 8) the relation of serum carotene and tocopherol fractions to squamous cell cancer (which includes cancer of the mouth, hypopharynx, esophagus, larynx, and lung); and 9) the association of certain serum trace elements (iron, zinc, copper) with cancer by specific type. Finally, a 30% systematic sample of the original subjects was also chosen for re-examination from 1970 to 1972, at which time fasting plasma triglycerides and lipoprotein fractions were measured. The association of plasma triglycerides and high, low and very low density lipoprotein with cancer risk at specific sites will be studied in this sub-sample of 2095 men.