EPIDEMIOLOGY & IMMUNOLOGY IN HOMOSEXUALS WITH PGL

流行病学

• 批准号: 3173843
• 负责人: ALEXANDRA M LEVINE
• 金额: $ 33.82万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-15 至 1987-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3173843
• 关键词: AIDS; B lymphocyte; Betaherpesvirinae; DNA; Epstein Barr virus; T lymphocyte; Toxoplasma; biopsy; blood chemistry; cancer risk; case history; cellular oncology; electrophoresis; gene expression; hepatitis B virus group; homosexuals; human T cell lymphotropic virus type 1; human subject; interleukin 2; karyotype; lymphoma; macrophage; microorganism immunology; molecular oncology; neoplasm /cancer immunodiagnosis; neoplasm /cancer immunology; oncogenes; questionnaires; serology /serodiagnosis; virus antigen; virus cytopathogenic effect

This document describes a proposal to investigate: (1) the development of malignant lymphoma in homosexual men with persistent, generalized lymphadenopathy (PGL) and AIDS-like immune dysfunction (acquired immunodeficiency syndrome); (2) factors responsible for the development of this state; and (3) the development of PGL or AIDS or malignant lymphoma in sexual contacts of these patients. Patients will be examined at 6 month intervals, and have serial lymph node biopsies and blood specimens taken. The lymph nodes will be investigated for morphologic expression, and for quantitative and qualitative changes in lymphocyte populations. In addition, DNA content analysis, oncogene expression, chromosomal karyotypes, and staining for various viral antigens (EB, CMV, HTLV) will be performed on the nodes. Serial evaluation of immunologic function will be performed at 6 monthly intervals, including B and T lymphocyte numbers and subsets, Interleukin I and II levels, natural killer and macrophage cytotoxicity. Serologic evidence of infection to a variety of agents (CMV, EB, HTLV, Hepatitis B, toxoplasmosis) will be studied. In addition, a careful epidemiologic evaluation will be performed. All of these parameters will be evaluated serially, in order to note changes which may be associated with the development of lymphoma. Patients will be compared to friend controls who are sexual contacts and with other homosexual controls by means of serial evaluation at six month intervals, with epidemiologic questionnaire, viral serologic and immunologic studies, identical to those performed on the patients, in order to discover those factors responsible for the development of the lymphadenopathy syndrome, or for lymphoma, or for AIDS in the normal homosexual population.

这份文件描述了一项调查建议：(1) 男同性恋者恶性淋巴瘤具有持续性、全身性 淋巴结病(PGL)和艾滋病样免疫功能障碍(获得性 免疫缺陷综合征)；(2)导致 这种状态；和(3)PGL或AIDS或恶性淋巴瘤的发展 这些患者的性接触。 患者将每隔6个月检查一次，并有连续的淋巴结 取活组织切片和血液样本。将对淋巴结进行检查 对于形态表达，以及对细胞的数量和质量变化 淋巴细胞群。此外，DNA含量分析，癌基因 各种病毒抗原的表达、染色体核型和染色 (EB、CMV、HTLV)将在节点上执行。系列评估 免疫功能将每6个月进行一次，包括B组 和T淋巴细胞数量和亚群，白细胞介素I和II水平，自然 杀人剂和巨噬细胞毒性。感染A型流感病毒的血清学证据 各种药物(CMV、EB、HTLV、乙肝、弓形虫病)将被 学习。此外，还将进行仔细的流行病学评估 已执行。所有这些参数将按顺序进行评估，以便 注意可能与淋巴瘤的发展有关的变化。 患者将与有性接触者和朋友对照组进行比较 在6个月时通过连续评估的方式与其他同性恋控制者进行比较 间隔时间，包括流行病学问卷、病毒血清学和 免疫学研究，与对患者进行的相同，按顺序 为了找出那些导致 淋巴结病综合征，或为淋巴瘤，或为艾滋病在正常情况下 同性恋人口。