NMR PROTON CHEMICAL SHIFT IMAGING

本研究的目标是改进质子核磁共振的能力 为了获取显示化学位移光谱信息的图像， 并评估这些方法在临床和体内的作用， 基础研究 与我们最初提交的报告一样， 调查将进行详细研究。 首先，脂质和水成像的定量技术， 在最初的融资期间，将进一步评估 扩展到测量额外的光谱特性。 这些 将包括光谱共振线展宽测量使用 非对称自旋回波（ASE）方法和标量耦合分数 (SCF)使用多重量子技术测量。 两个应用程序 都计划好了 在资助的试点研究取得成功之后， 在最初的研究期间， 脂质和水共振浓度的定量分析， 弛豫时间和新开发的谱线测量 将在骨髓疾病中评估宽度。 这将 包括骨髓增生的详细纵向研究， 化学位移成像（CSI）的初步研究 测量骨髓铁储备的技术。 研究也将开始 动脉粥样硬化斑块的定量光谱成像。 工作 将重点关注脂肪斑块的特征与脂质- 敏感和多量子脉冲序列，以及动脉粥样硬化 动脉血栓与铁敏感线宽映射。 这些 研究将致力于建立量化的CSI， 用于评估动脉病变反应的非侵入性工具 激光血管成形术等新的干预措施。 其次，绘制脑缺血中的乳酸将形成 大脑生理学研究的基石 技术问题 将包括改进的脂质抑制方法 （以前的工作已经证明了解决问题的办法， 体内水抑制）和场强之间的比较。 生理学与乳酸图相关，包括MR和PET 测量脑血流量、脑pH值和氧代谢， 将用于全身缺氧和局灶性缺血， 大脑能量代谢和pH调节的问题。

The goal of this research is to refine the capacity of proton NMR to acquire images displaying chemical shift spectral information, and to assess the role of these methods in vivo in clinical and basic research. As in our initial submission, two areas of investigation will be studied in detail. First, quantitative techniques of lipid and water imaging, evaluated during the initial funding period, will be further extended to measure additional spectral characteristics. These will include spectral resonance line broadening measured using an asymmetric spin echo (ASE) method, and scalar coupled fraction (SCF) measured using multiple quantum techniques. Two applications are planned. Following on the success of pilots studies funded during the initial study period, the clinical utility of quantitative analysis of lipid and water resonance concentration, relaxation times, and newly developed measures of spectral line widths will be evaluated in disorders of bone marrow. This will include detailed longitudinal studies of myeloproliferative disorders, and pilot studies of chemical shift imaging (CSI) techniques to measure marrow iron stores. Research will also begin on quantitative spectral imaging of atherosclerotic plaque. Work will focus on characterization of fatty plaques with lipid- sensitive and multiple quantum pulse sequences, and atherosclerotic arterial thrombus with iron-sensitive line width mapping. These studies will be directed towards establishing quantitative CSI as a non-invasive tool for evaluating the response of arterial lesions to new interventions such as laser angioplasty. Second, mapping lactate in cerebral ischemia will form the cornerstone of studies of brain physiology. Technical issues to be addressed will include improved methods of lipid suppression (previous work having demonstrated solutions to the problem of in vivo water suppression), and comparison between field strengths. Physiologic correlates to lactate maps including MR and PET measures of cerebral blood flow, brain pH and oxygen metabolism, will be used in both global hypoxia and focal ischemia to address questions of brain energy metabolism and pH regulation.