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Upgrade the 14T Ultrahigh Field Horizontal MR Scanner for Rodent and ex-vivo Imaging

升级 14T 超高场水平 MR 扫描仪，用于啮齿动物和离体成像

基本信息

批准号：
10175835
负责人：
BRUCE R ROSEN
金额：
$ 60万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2024-04-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10175835
关键词：
Alzheimer&apos s Disease Anatomy Animal Disease Models Animal Model Animals Biosensor Brain Brain Diseases Brain Mapping Calcium Coma Dementia Diffusion Magnetic Resonance Imaging Electronics Functional Magnetic Resonance Imaging Funding General Hospitals Glutamates Goals Heart Arrest Hepatic Fibrogenesis Hepatitis Human Image Magnetic Resonance Imaging Massachusetts Mediating Methodology Methods Migraine Multimodal Imaging Organ Parkinson Disease Performance Research Personnel Research Project Grants Resolution Resources Rodent Signal Transduction Software Design System Techniques Tissue imaging Translations Traumatic Brain Injury United States National Institutes of Health animal imaging base brain tissue cerebrovascular ex vivo imaging functional MRI scan imaging platform improved instrument multidisciplinary multimodality neuroimaging neurovascular next generation novel optical fiber optogenetics pre-clinical technological innovation translational study

项目摘要

The goal of this proposal is to purchase a Bruker AV-Neo console to replace the out-of-date Siemens console of the 14T horizontal MR scanner (13cm bore), which has been dedicated to supporting the high-resolution anatomical and functional dynamic brain mapping of animals and ex-vivo human brain tissue imaging. The Martinos Center at the Massachusetts General Hospital has been at the forefront of developing advanced functional mapping methods, e.g., functional MRI, and implementing the cutting-edge MRI methods to bridge the basic and translational studies. To pursue the next-generation cutting-edge imaging methodology and prepare for the higher field MRI translational studies, there is an urgent need to improve our 14T MRI preclinical platform for high-resolution animal and ex vivo imaging. In particular, the proposed 14T MR console upgrade will boost the translational potentials of the novel methodology, e.g. the single- vessel fMRI and line-scanning fMRI, to bridge cellular and microvascular anatomy and functional dynamics from animal to human brains. Also, this proposal will support over 20 research projects funded by NIH, presenting critical translational efforts on the mechanistic studies of brain disorders including Alzheimer’s Diseases (AD), Parkinson’s Disease, cerebrovascular dementia, migraine, traumatic brain injury, and cardiac arrest (AC)-induced coma, as well as for the internal organ imaging of animal models with hepatitis and hepatic fibrogenesis. The highly synergistic and collaborative research projects outlined in our proposal can be summarized in three main themes: 1) Neurovascular dynamic signaling, 2) Cutting-edge neuroimaging methodology, 3) Multimodal mechanistic signatures of animal disease models. We have established the 14T- based multi-modal imaging platform to combine the high-resolution anatomical and functional MRI imaging with the emerging neuro-techniques, e.g. optogenetics, optical fiber-mediated biosensor recording of Calcium, Glutamate, etc, promoting novel mechanistic understanding of the complexity of brain function. The Bruker AV-Neo system will provide key technological innovations to improve the performance of the novel brain mapping methods, e.g. the single-vessel fMRI, line- scanning fMRI, RF slab-specific diffusion-weighted MRI, based on the state-of-the-art electronics and software design. Therefore, the proposed instrument upgrade would not only accelerate the progress of the listed projects but also facilitate the translation of cutting-edge MR methodologies as a truly multidisciplinary, regional resource for PHS funded investigators.

该提案的目标是购买布鲁克AV-Neo控制台，以取代过时的西门子14 T水平MR扫描仪（13 cm孔径）控制台，专用于支持动物的高分辨率解剖和功能动态脑映射，离体人脑组织成像。马萨诸塞州总医院的马蒂诺斯中心一直处于开发高级功能映射方法的前沿，例如，功能磁共振成像，并实施最先进的磁共振成像方法，以弥合基础和翻译问题研究追求下一代尖端成像方法，为更高场MRI转化研究，迫切需要改善我们的14 T MRI临床前高分辨率动物和离体成像平台。特别是，拟议的14 T MR 控制台的升级将提高新方法的转化潜力，例如，血管功能磁共振成像和线扫描功能磁共振成像，桥梁细胞和微血管解剖和功能从动物大脑到人类大脑的动力学。此外，该提案将支持20多个研究项目由美国国立卫生研究院资助，提出了关键的翻译努力的机制研究大脑包括阿尔茨海默病（AD）、帕金森病、脑血管痴呆、偏头痛，创伤性脑损伤和心脏骤停（AC）引起的昏迷，以及内部肝炎和肝纤维化动物模型的器官成像。高度协同和合作研究项目概述了我们的建议，可以概括为三个主要的主题：1）神经血管动态信号，2）尖端神经影像学方法，3）动物疾病模型的多模态机制特征。我们已经建立了14 T- 基于多模态成像平台，联合收割机高分辨率解剖和功能MRI 用新兴的神经技术成像，例如光遗传学、光纤介导的生物传感器记录钙、谷氨酸等，促进对大脑功能的复杂性。布鲁克AV-Neo系统将提供关键的技术创新为了提高新的脑映射方法的性能，例如单血管功能磁共振成像，线- 扫描功能磁共振成像，RF板特异性扩散加权磁共振成像，基于最先进的电子学和软件设计。因此，拟议的仪器升级不仅将加快不仅有助于所列项目的进展，而且还有助于最先进的MR方法的翻译作为一个真正的多学科，为公共卫生服务资助的调查人员的区域资源。