Center for Mesoscale Mapping

中尺度测绘中心

• 批准号: 10038177
• 负责人: BRUCE R ROSEN
• 金额: $ 173.15万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10038177
• 关键词: 3-Dimensional; Acceleration; Address; Alzheimer' s Disease; Anatomic Models; Basic Science; Biological; Brain; Brain Stem; Cell Nucleus; Cerebral Palsy; Communities; Computer Models; Computer software; Consensus; Data; Data Set; Development; Devices; Diffusion; Disease; Educational process of instructing; Educational workshop; Electroencephalography; Electromagnetics; Electrophysiology (science); Epilepsy; Evaluation; Event; Fiber; Frequencies; Functional Magnetic Resonance Imaging; Generations; Goals; Histologic; Human; Image; Investigation; Link; Machine Learning; Magnetic Resonance Imaging; Maps; Measures; Mental Depression; Mental disorders; Microscopic; Mind; Modeling; Molecular; Morphologic artifacts; Motion; Multiple Sclerosis; Neurons; Neurosciences; Online Systems; Performance; Peripheral Nerve Stimulation; Property; Publications; Research Personnel; Resolution; Resources; Respiration; Scanning; Services; Signal Transduction; Sleep Disorders; Slice; Space Models; Spatial Distribution; Structure; Surface; System; Techniques; Technology; Time; Training; Training Programs; Transcranial magnetic stimulation; Visualization; Work; base; cognitive neuroscience; data space; deep learning; design; electric field; frontier; human disease; human imaging; improved; in vivo; industry partner; instrumentation; machine learning algorithm; nervous system disorder; neuroimaging; novel; open source; post-doctoral training; pre-doctoral; reconstruction; relating to nervous system; response; spatiotemporal; tool; tool development; translational neuroscience; usability; white matter

Overview of the Proposed Resource – Abstract The goal of the Center for Mesoscale Mapping is to drive the convergence of microscopic- and macroscopic- scale evaluation of brain structure and function for human translational neuroscience, by developing and applying tools to study the spatial distribution and temporal orchestration of mesoscopic events in the human brain. Our Collaborators will, through a dynamic “push-pull” relationship, provide unique problems which drive the development of these tools, and in return guide us in the design and optimization of our toolbox for practical use in a variety of normal and disease settings. While there is still no formal consensus on the definition of mesoscopic within the neuroscience community, we take as our guide the spatial and temporal scales at which local groups of neurons act in coherent fashion – in the cortex, this includes the spatial scale of columns and laminar structures (between ~0.1-1 mm), while in deeper structures includes the myriad of deep brain and brainstem nuclei. Preliminary data from our own center, and of course others throughout the world, now support the notion that we are on the threshold of being able to map, measure and perturb the human brain at these scales, and do so comprehensively across wide swaths of the human brain. Temporally too, recent advances suggest a convergence between temporal scales addressable with tools like fMRI, which can now investigate delta frequency coherent phenomena, and advanced electromagnetic tools to measure and perturb coherent electrophysiological activity at higher frequencies still. With this convergence in mind, the tools we proposed to develop within the TRDs of the CMM will provide our Collaborative and Service User community with the important “missing links” between the advances in human cognitive neuroscience at the “system level,” and the enormous strides in cellular level circuit functional characterization. Our Collaborators will bring their own unique challenges to help us define and further refine these tools, offering problems requiring distinct measures of human brain structural and functional properties in a variety of normal and disease settings. Our Service Users will utilize our tools to better understand human neural systems, and particularly human disease states from multiple sclerosis to Alzheimer’s, to depression and epilepsy. Finally, our Center will seek to disseminate these tools, through open-source software and hardware designs, industrial partnerships and “hands-on” teaching courses for hardware, and to train a new generation of human neuroscientists in the use of our advanced tools to explore the human brain at this next frontier.

拟议资源概述 - 摘要 中尺度测绘中心的目标是推动微观和宏观的融合 通过开发和应用，对人类转化神经科学的大脑结构和功能进行规模评估 研究人脑介观事件的空间分布和时间编排的工具。我们的 合作者将通过动态的“推拉”关系，提供独特的问题来推动 开发这些工具，并指导我们设计和优化我们的工具箱以供实际使用 在各种正常和疾病环境中。尽管对于定义的定义尚未达成正式共识 在神经科学界的介观范围内，我们以空间和时间尺度为指导 局部神经元组以连贯的方式起作用——在皮层中，这包括柱的空间尺度和 层状结构（~0.1-1毫米之间），而更深的结构包括无数的深层大脑和 脑干核团。来自我们自己的中心以及世界各地其他中心的初步数据现在支持 我们即将能够在这些方面绘制、测量和扰动人类大脑 规模，并在人类大脑的大范围内全面进行。暂时也是如此，最近的进展 建议使用功能磁共振成像等工具可寻址的时间尺度之间的收敛，现在可以研究 德尔塔频率相干现象，以及用于测量和扰乱相干的先进电磁工具 电生理活动的频率仍然较高。考虑到这种融合，我们提出的工具 在 CMM 的 TRD 内开发将为我们的协作和服务用户社区提供 人类认知神经科学在“系统层面”的进步与 细胞级电路功能表征方面取得了巨大进步。我们的合作者将带来他们自己独特的 帮助我们定义和进一步完善这些工具的挑战，提出了需要采取不同措施的问题 各种正常和疾病环境下的人脑结构和功能特性。我们的服务用户 将利用我们的工具更好地了解人类神经系统，特别是人类疾病状态 多发性硬化症、阿尔茨海默氏症、抑郁症和癫痫症。最后，我们中心将努力传播这些 工具，通过开源软件和硬件设计、行业合作伙伴关系和“实践”教学 硬件课程，并培训新一代人类神经科学家使用我们的先进工具 探索人类大脑的下一个前沿领域。