Technical development of a novel vaccine vehicle for cattle pathogens

新型牛病原体疫苗载体的技术开发

• 批准号: BB/L02442X/1
• 负责人: Keith Matthews
• 金额: $ 38.88万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL02442X%2F1
• 关键词: Technical; development; novel; vaccine; vehicle

Trypanosoma theileri is a ubiquitous single celled organism present in cattle herds worldwide. Using knowledge of gene expression and protein trafficking in other trypanosomatid organisms, we have successfully developed T. theileri as a delivery system for vaccine antigens and therapeutics. Following recommendations from several Animal Health companies, we now aim to develop and demonstrate the potential of T. theileri as an effective and practical vaccine-vehicle, providing a clear route to commercialisation.In a two-step development path, Phase 1 will focus on technical refinements and analysis of the viability of the vaccine-vehicle during storage and distribution. The flexibility of the system to express antigens from a range of pathogens will also be established. Phase 2 will entail confirmation of the in vivo efficacy of the refinements developed in Phase 1.Combined the experiments will address key hurdles to the commercial development of this patented vaccine system.

泰氏锥虫是一种普遍存在于世界各地牛群中的单细胞生物。利用其他锥虫生物体中基因表达和蛋白质运输的知识，我们成功地开发了T。作为疫苗抗原和治疗剂的递送系统。根据几家动物保健公司的建议，我们现在的目标是开发和展示T。作为一种有效和实用的疫苗载体，为商业化提供了一条清晰的道路。在两步发展道路中，第一阶段将专注于技术改进和疫苗载体在储存和分销期间的可行性分析。还将建立系统表达来自一系列病原体的抗原的灵活性。第二阶段将需要确认第一阶段开发的改进的体内功效。结合这些实验，将解决这种专利疫苗系统商业开发的关键障碍。

项目成果

An Alternative Strategy for Trypanosome Survival in the Mammalian Bloodstream Revealed through Genome and Transcriptome Analysis of the Ubiquitous Bovine Parasite Trypanosoma (Megatrypanum) theileri.

• DOI: 10.1093/gbe/evx152
• 发表时间: 2017-08-01
• 期刊: Genome biology and evolution
• 影响因子: 3.3
• 作者: Kelly S;Ivens A;Mott GA;O'Neill E;Emms D;Macleod O;Voorheis P;Tyler K;Clark M;Matthews J;Matthews K;Carrington M
• 通讯作者: Carrington M

The genomic basis of host and vector specificity in non-pathogenic trypanosomatids.

• DOI: 10.1242/bio.059237
• 发表时间: 2022-04-15
• 期刊: Biology open
• 影响因子: 2.4

Comparative Sensitivity and Specificity of the 7SL sRNA Diagnostic Test for Animal Trypanosomiasis.

• DOI: 10.3389/fvets.2022.868912
• 发表时间: 2022
• 期刊: Frontiers in veterinary science
• 影响因子: 3.2