RECTOSIGMOID POLYPS AND RISK OF COLORECTAL CANCER

我们的目标是发展良性直肠乙状结肠的关系知识 息肉和结肠癌（包括直肠）。 具体的目标是 对结肠癌患者死亡率的评估 或更多经手术证实的息肉和结肠直肠癌的比较 发病率和死亡率，根据组织学特征， 以前切除的息肉。 建议进行回顾性随访研究。 一 一组2,500名男性和女性， 大肠息肉（主要是直肠乙状结肠）将通过使用 罗得岛州医院的病理学记录 受试者将 在1959年至1970年期间，他们的指数录取，将是35-79 岁，当时。 该队列将通过使用医疗 记录，死亡证明，城市目录，以及其他现有的 资源 所有病例的良性组织切片将被取出 和非病例的样本。 的 将根据标准方案审查载玻片，以评估 息肉的特征，特别是区分肿瘤性和 增生性息肉，并评估绒毛成分（如有）和 发育不良的程度和严重程度。 美国的结肠癌死亡率 将队列与罗得岛居民的发病率进行比较 相同的年龄和性别分布。 通过使用内病例对照， 采用队列方法，结肠癌的发病率和死亡率将 与切除的良性组织的组织学特征相关。 死亡 也将评估其他原因的复发率， 估计大肠息肉。 调查结果将影响到 结肠息肉的自然病史，以及对人的临床预后 在这种情况下。 结果可能有助于规划后续行动 结肠息肉患者的治疗方案和结肠筛查计划 癌

The goal is to develop knowledge of the relationship of benign rectosigmoid polyps and cancer of the colon (including the rectum). Specific aims are evaluation of the colon cancer mortality rate in persons who have had one or more surgically-confirmed polyps and comparison of colo-rectal cancer incidence and death rates according to histologic features of the previously removed polyps. A retrospective follow-up study is proposed. A population-based group of 2,500 men and women with surgically-confirmed large bowel polyps (primarily rectosigmoid) will be identified by use of pathology records in Rhode Island hospitals state-wide. Subjects will have had their index admission in the period 1959-70, and will have been 35-79 years old at that time. The cohort will be followed up by use of medical records, death certificates, city directories, and other existing resources. Slides of the benign tissue will be retrieved for all the cases of colon cancer that are identified, and for a sample of non-cases. The slides will be reviewed according to a standard protocol in order to assess the features of the polyps, especially to distinguish neoplastic from hyperplastic polyps, and to assess the villous component (if any) and the extent and severity of dysplasia. The death rate from colon cancer in the cohort will be compared to the rate experienced by Rhode Island residents with the same age and sex distribution. By use of the case-control within a cohort approach, the incidence and mortality rates from colon cancer will be correlated with histologic features of the benign tissue removed. Death rates from other causes also will be evaluated, and rates of recurrence of large bowel polyps will be estimated. The findings will bear on the natural history of colon polyps, and on the clinical prognosis of people with this condition. The results may be useful in planning follow-up protocols for patients with colon polyps and screening programs for colon cancer.