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RECTOSIGMOID POLYPS AND RISK OF COLORECTAL CANCER

直肠乙状结肠息肉和结直肠癌的风险

基本信息

批准号：
3183311
负责人：
ALAN S. MORRISON
金额：
$ 12.86万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
起止时间：
1986-09-01 至 1990-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3183311
关键词：
cancer information system cancer registry /resource cancer risk carcinoma histopathology human mortality human subject longitudinal human study neoplasm /cancer relapse /recurrence prognosis rectosigmoid neoplasm rectum neoplasms

项目摘要

The goal is to develop knowledge of the relationship of benign rectosigmoid polyps and cancer of the colon (including the rectum). Specific aims are evaluation of the colon cancer mortality rate in persons who have had one or more surgically-confirmed polyps and comparison of colo-rectal cancer incidence and death rates according to histologic features of the previously removed polyps. A retrospective follow-up study is proposed. A population-based group of 2,500 men and women with surgically-confirmed large bowel polyps (primarily rectosigmoid) will be identified by use of pathology records in Rhode Island hospitals state-wide. Subjects will have had their index admission in the period 1959-70, and will have been 35-79 years old at that time. The cohort will be followed up by use of medical records, death certificates, city directories, and other existing resources. Slides of the benign tissue will be retrieved for all the cases of colon cancer that are identified, and for a sample of non-cases. The slides will be reviewed according to a standard protocol in order to assess the features of the polyps, especially to distinguish neoplastic from hyperplastic polyps, and to assess the villous component (if any) and the extent and severity of dysplasia. The death rate from colon cancer in the cohort will be compared to the rate experienced by Rhode Island residents with the same age and sex distribution. By use of the case-control within a cohort approach, the incidence and mortality rates from colon cancer will be correlated with histologic features of the benign tissue removed. Death rates from other causes also will be evaluated, and rates of recurrence of large bowel polyps will be estimated. The findings will bear on the natural history of colon polyps, and on the clinical prognosis of people with this condition. The results may be useful in planning follow-up protocols for patients with colon polyps and screening programs for colon cancer.

其目的是发展对良性直肠乙状结肠的关系的认识。息肉和结肠癌(包括直肠)。具体目标是曾患结肠癌的人群中结肠癌死亡率的评估或更多经手术证实的息肉与结直肠癌的比较根据组织学特征的发病率和死亡率之前切除的息肉。建议进行一项回顾性的随访研究。一个以人口为基础的2500名男性和女性患者，经手术证实大肠息肉(主要是直肠乙状结肠)将通过使用罗德岛全州医院的病理记录。受试者将拥有在1959-70年期间有他们的指数录取，并将一直在35-79 当时他已经15岁了。该队列将通过使用医疗工具进行跟踪记录、死亡证明、城市名录和其他现有的资源。所有病例的良性组织切片都将被取回已确诊的结肠癌，以及非病例的样本。这个将根据标准方案审查幻灯片，以便评估息肉的特征，特别是要与肿瘤性息肉相鉴别增生性息肉，并评估绒毛成分(如果有)和异型增生的范围和严重程度。中国结肠癌的死亡率队列将与罗德岛居民经历的比率进行比较具有相同的年龄和性别分布。通过使用内部的病例对照采用队列方法，结肠癌的发病率和死亡率将与切除的良性组织的组织学特征相关。死亡其他原因的复发率也将进行评估，大肠息肉将被估计。这些发现将影响到结肠息肉的自然病史及其对临床预后的影响在这种情况下。研究结果可能对计划后续行动有帮助。结肠息肉患者的治疗方案和结肠筛查程序癌症。