HORMONES AND RISK OF PROSTATIC HYPERLASIA

激素与前列腺增生的风险

• 批准号: 3243270
• 负责人: ALAN S. MORRISON
• 金额: $ 27.63万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3243270
• 关键词: androstenedione; benign prostate hyperplasia; carotene; diet; dietary lipid; dihydrotestosterone; disease /disorder proneness /risk; estradiol; estrone; hormone regulation /control mechanism; human tissue; longitudinal human study; nutrient intake activity; nutrition related tag; questionnaires; radioimmunoassay; testosterone; tobacco; tobacco abuse

The long-term goal is the development of preventive or therapeutic measures for benign prostatic hyperplasia (BPH). The principal specific aim is to evaluate the relations of the hormone profile to surgery to BPH. This aim will be met by a "nested" case-control analysis of blood specimens and other data collected in the Physicians' Health Study (PHS). The PHS is a randomized trial of aspirin and beta-carotene in the prevention of cardiovascular mortality and cancer incidence, conducted among U.S male physicians 40-84 years of age. The subjects completed questionnaires at entry, and follow-up has been done by use of questionnaires at 6 months, 12 months, and annually thereafter. As part of the trial, blood samples were collected before randomization and stored t -82 C. The specimens for 400 participants who had surgery for BPH and 400 controls will be retrieved and analyzed for testosterone, dihydrotestosterone, delta4-androstenedione, estrone, and estradiol. Mean hormone levels will be compared between cases and controls, and the relative incidence of surgically-confirmed BPH will be estimated according to quintiles of hormone levels. The secondary aim of the study is to evaluate the associations of BPH with cigarette smoking and components of the diet, especially beta-carotene and fat intake. This aim will be met by use of data collected on the entry and follow-up questionnaires on all 22,071 participants.

长期目标是制定预防或治疗措施 治疗良性前列腺增生症 主要的具体目标是 评价激素水平与BPH手术治疗的关系。 这一目标 将通过对血液标本进行“巢式”病例对照分析， 医生健康研究（PHS）中收集的其他数据。 PHS是一个 阿司匹林和β-胡萝卜素预防糖尿病的随机试验 心血管死亡率和癌症发病率，在美国男性中进行 年龄在40-84岁之间的医生。 受试者完成问卷调查， 入组，并在6个月、12个月和14个月时使用问卷进行随访。 月，此后每年。 作为试验的一部分， 在随机化前收集并储存在-82 ℃。 400个标本 将检索接受BPH手术的参与者和400名对照者， 分析睾酮、双氢睾酮、δ 4-雄烯二酮， 雌酮和雌二醇。 将比较病例之间的平均激素水平 与对照组相比，经病理证实的BPH的相对发病率将 根据激素水平的五分位数来估计。 次要目的 这项研究的目的是评估前列腺增生与吸烟的关系 和饮食成分，特别是β-胡萝卜素和脂肪的摄入量。 这 将通过使用在进入和后续行动中收集的数据来实现目标 对22,071名参与者进行问卷调查。