HORMONES IN THE EPIDEMIOLOGY OF PROSTATIC HYPERPLASIA

这项研究的长期目标是发展预防性或 良性前列腺增生症的治疗措施。具体的 目的是评估激素谱与手术治疗的关系。 以评估吸烟与激素之间的关系 水平，并评估吸烟和其他环境因素之间的关系 影响BPH和荷尔蒙水平的因素，尤其是饮食。一件案子- 提出了控制研究的思路。这一系列案件将有500名男子生活在 罗德岛州在5月份进行了第一次前列腺增生症手术， --1992年4月。将从1,000个控件中选择一系列 研究区域的居民。受试者将在家中接受采访， 尊重吸烟和饮食历史。饮食历史将使用 食物频率法辅以食物模型以帮助估计 份量。受试者也将被要求提供血液样本 采访结束后。来自每个受试者的血清将被汇集并分析 对于自由和结合的睾酮，脱氢睾酮，自由和结合的 雌二醇、雌酮、β-雄烯二酮、雄烯二醇和 催乳素。经手术证实的前列腺增生症的相对发病率将为 根据荷尔蒙水平的五分之一估计，根据 吸烟史和营养素摄入量，包括饱和总脂肪 脂肪、类胡萝卜素和纤维。根据来自控件的信息， 吸烟和营养摄入量将与荷尔蒙水平有关。

The long-term goal of this study is the development of preventive or therapeutic measure for benign prostatic hyperplasia (BPH). The specific aims are to evaluate the relations of the hormone profile to surgery for BPH, to evaluate the associations of cigarette smoking with hormone levels, and to evaluate associations of smoking and other environmental factors, especially diet, to BPH and to the hormone profile. A case- control study is proposed. The case series will be 500 men living in Rhode Island who have their first operation for BPH in the period May, 1989 - April, 1992. A series of 1,000 controls will be selected from residents of the study area. Subjects will be interviewed at home with respect to smoking and dietary histories. The dietary history will use the food frequency method supplemented with food models to help estimate portion size. Subjects will also be asked for blood specimens before and after the interview. Serum from each subject will be pooled and analyzed for free and bound testosterone, dehydrotestosterone, free and bound estradiol, estrone, delta4-androstenedione, androstanediol, and prolactin. The relative incidence of surgically-confirmed BPH will be estimated according to quintile of hormone levels, and according to smoking history and intakes of nutrients including total fat, saturated fat, carotenoids and fiber. Based on information from the controls, cigarette smoking and nutrient intakes will be related to hormone levels.