CIGARETTE SMOKING AND BENIGN PROSTATIC HYPERPLASIA

这项研究的长期目标是发展预防性或 良性前列腺增生症的治疗措施。校长 具体目的是评估吸烟对死亡率的影响。 关于良性前列腺增生症的手术。为了达到这一目的，我们提出了病例对照研究。 80岁以下的男性在一年内进行了第一次BPH手术 罗德岛州将在全州范围内确定21个月的期限， 和控制组将从男性居民名单中随机选择 状态，按年龄进行频率匹配。病例(1000例)和对照(2000例) 将通过电话采访他们吸烟的情况 历史和其他选定的环境暴露。相对AND 经手术证实的良性前列腺增生症的归因风险将在 吸烟者和戒烟者与不吸烟者相比，风险将被评估 根据吸烟量和戒烟后的时间。的幻灯片 切除的前列腺组织将根据标准方案进行审查 为了评估增生性成分的特征，特别是 上皮细胞和其他良性病变。吸烟的影响 将评估具有不同组织学特征的BPH的亚型。 根据从控制组获得的信息，吸烟也 会不会与良性前列腺增生症的症状发展有关 从外科手术开始。最后，前列腺增生症与喝咖啡、饮酒的关系 将对消费和职业进行探索。

The long-term goal of this study is the development of preventive or therapeutic measures for benign prostatic hyperplasia (BPH). The principal specific aim is estimation of the effect of cigarette smoking on the rate of surgery for BPH. A case-control study is proposed to achieve this aim. Men under age 80 years who have had their initial operation for BPH in a 21-month period will be identified on a state-wide basis in Rhode Island, and controls will be selected at random from lists of male residents of the state, with frequency matching by age. Cases (1000) and controls (2000) will be interviewed by telephone regarding their cigarette-smoking histories and other selected environmental exposures. Relative and attributable risks of surgically-confirmed BPH will be estimated in current smokers and ex-smokers, compared to nonsmokers, and risks will be evaluated according to amount smoked and to time since stopping. Slides of the prostatic tissue removed will be reviewed according to a standard protocol in order to assess the features of the hyperplastic component, especially the epithelium, and other benign changes. The effect of cigarette smoking will be evaluated for sub-types of BPH with different histologic features. Based on information obtained from the controls, cigarette smoking also will be related to the development of symptoms of BPH not treated surgically. Finally, associations of BPH with coffee-drinking, alcohol consumption and occupation will be explored.