METABOLISM AND BIOAVAILABILITY OF MEIOX FROM FRIED BEEF
油炸牛肉中 MEIOX 的代谢和生物利用度
基本信息
- 批准号:3181296
- 负责人:
- 金额:$ 11.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1985
- 资助国家:美国
- 起止时间:1985-09-01 至 1989-08-31
- 项目状态:已结题
- 来源:
- 关键词:DNA biotransformation cancer risk chemical carcinogen chemical carcinogenesis chemical related neoplasm /cancer chemical synthesis detoxification dietary constituent excretion gastrointestinal toxin absorption high performance liquid chromatography liver metabolism mutagen testing mutagens nutrition aspect of cancer nutrition related neoplasm /cancer nutrition related tag quinoxalines radiopharmacology radiotracer toxicant screening toxin metabolism tritium
项目摘要
The overall objectives of the proposed work are to determine the metabolism
and bioavailability of the mutagen MeIQx, as it occurs in the crust of
fried beef. In order to characterize bioavailability of this substance we
plan to specify routes of metabolic activation and deactivation, and
macromolecular binding, in vitro and in vivo. In addition, absorption,
excretion and tissue disposition of MeIQx and its metabolites will be
determined. The proposed work is a collaborative effort which combines
studies in synthetic chemistry and in metabolism. The specific objectives
of the synthetic work are: 1) synthesis of MeIQx and [C14] MeIQx, 2)
synthesis of [14C] N-OH-MeIQx, 3) preparation of a MeIQx-nucleotide adduct,
and 4) synthesis of likely detoxification products of MeIQx. The
objectives of the metabolism studies are: 1) identification of activated
and deactivated metabolites of MeIQx, in vitro, and 2) absorption,
distribution, excretion, and macromolecular binding in vivo, of MeIQx
incorporated in beef crust.
MeIQx is the most prevelent of the heterocyclic mutagens and carcinogens
which occur in fried meat. A unique feature of these substances is their
localization in the crust of fried meat. This characteristic may affect
the extent to which the compounds are absorbed in the gastronintestinal
tract and consequently the toxic effects of the substances. An
understanding of the effects of meat on the biochemical characteristics of
the mutagen is rquired for efforts to extrapolate results with animals to
estimates of human risk.
拟议工作的总体目标是确定代谢
和生物利用度的诱变剂MeIQx,因为它发生在地壳的
炸牛肉。 为了表征该物质的生物利用度,
计划指定代谢活化和失活途径,以及
大分子结合,在体外和体内。 此外,吸收,
MeIQx及其代谢产物的排泄和组织处置将
测定 拟议的工作是一项合作努力,
研究合成化学和新陈代谢。 的具体目标
主要的合成工作有:1)MeIQx和[C14] MeIQx的合成,2)
[14 C] N-OH-MeIQx合成,3)MeIQx-核苷酸加合物的制备,
(4)合成MeIQx可能的解毒产物。 的
代谢研究的目的是:1)鉴定活化的
和MeIQx的失活代谢物,2)吸收,
MeIQx的体内分布、排泄和大分子结合
加入了牛肉脆皮
MeIQx是最常见的杂环诱变剂和致癌物
在炸过的肉里。 这些物质的一个独特特征是它们
定位在炸肉的外壳中。 这一特点可能会影响
化合物在胃肠中吸收的程度
因此,这些物质的毒性作用。 一个
了解肉类对生物化学特性的影响,
诱变剂是需要努力外推结果与动物,
评估人类风险。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('HENRY RAPOPORT', 18)}}的其他基金
METABOLISM AND BIOAVAILABILITY OF MEIOX FROM FRIED BEEF
油炸牛肉中 MEIOX 的代谢和生物利用度
- 批准号:
3181297 - 财政年份:1985
- 资助金额:
$ 11.15万 - 项目类别:
METABOLISM AND BIOAVAILABILITY OF MEIOX FROM FRIED BEEF
油炸牛肉中 MEIOX 的代谢和生物利用度
- 批准号:
3181294 - 财政年份:1985
- 资助金额:
$ 11.15万 - 项目类别:
METABOLISM AND BIOAVAILABILITY OF MEIOX FROM FRIED BEEF
油炸牛肉中 MEIOX 的代谢和生物利用度
- 批准号:
3181295 - 财政年份:1985
- 资助金额:
$ 11.15万 - 项目类别:
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