STRUCTURE OF PROTEIN-BOUND BILE PIGMENTS

蛋白质结合胆汁色素的结构

• 批准号: 3276412
• 负责人: HENRY RAPOPORT
• 金额: $ 18.75万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-05-01 至 1992-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3276412
• 关键词: bile pigments; binding proteins; chemical bond; chemical group; chemical structure; fluorescent dye /probe; nuclear magnetic resonance spectroscopy; peptide structure; phycobilin; protein biosynthesis; protein sequence; protein structure; stereochemistry; stereoisomer; tetrapyrroles

Proteins with covalently bound heme and tetrapyrrole (bile pigment) prosthetic groups are a class of brilliantly clored, intensely fluorescent compounds found in all organisms. They have important roles in electron transport, photochemical reactions, and metabolic processes. The objectives of this investigation are to establish the structure and absolute stereochemistry of each pigement-peptide moiety, to establish the detailed biosynthetic mechanism by which each pigment-protein combination is formed, and to develop synthetic methods so that these molecules and their analogues will be available for structure-activity studies.

具有共价结合血红素和四吡咯（胆汁色素）的蛋白质 假体基团是一类颜色鲜艳、发出强烈荧光的 所有生物体中都存在的化合物。 它们在电子领域发挥着重要作用 运输、光化学反应和代谢过程。 这 本次调查的目的是建立结构和 每个色素肽部分的绝对立体化学，以确定 每种色素-蛋白质组合的详细生物合成机制 形成，并开发合成方法，使这些分子和 它们的类似物将可用于结构活性研究。