STRUCTURE OF PROTEIN-BOUND BILE PIGMENTS

蛋白质结合胆汁色素的结构

• 批准号: 3276408
• 负责人: HENRY RAPOPORT
• 金额: $ 18.52万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-05-01 至 1992-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3276408
• 关键词: bile pigments; chemical bond; chemical group; chemical structure; fluorescent dye /probe; nuclear magnetic resonance spectroscopy; stereochemistry; stereoisomer; tetrapyrroles

Proteins with covalently bound heme and tetrapyrrole (bile pigment) prosthetic groups are a class of brilliantly clored, intensely fluorescent compounds found in all organisms. They have important roles in electron transport, photochemical reactions, and metabolic processes. The objectives of this investigation are to establish the structure and absolute stereochemistry of each pigement-peptide moiety, to establish the detailed biosynthetic mechanism by which each pigment-protein combination is formed, and to develop synthetic methods so that these molecules and their analogues will be available for structure-activity studies.

具有共价结合血红素和四吡咯（胆色素）的蛋白质 辅基是一类明亮的封闭的， 在所有生物体中发现的化合物。 它们在电子中起着重要的作用 运输、光化学反应和代谢过程。 的 本次调查的目的是建立结构， 每个色素-肽部分的绝对立体化学，以建立 每种色素-蛋白质组合的详细生物合成机制 形成，并开发合成方法，使这些分子和 它们的类似物将可用于结构-活性研究。