Using a Designer Receptor Exclusively Activated by Designer Drug to define the role of short chain fatty acids in metabolic disease and inflammation

使用由设计药物独家激活的设计受体来定义短链脂肪酸在代谢疾病和炎症中的作用

• 批准号: BB/L02781X/1
• 负责人: Andrew Tobin
• 金额: $ 71.75万
• 依托单位: MRC Toxicology Unit
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL02781X%2F1
• 关键词: Using; Designer; Receptor; Exclusively; Activated

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前，所有资助研究的摘要都不能在GTR中找到。这通常是因为在提交提案时并不需要摘要，但可能是因为它包含了个人详细信息等敏感信息。

项目成果

Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling.

• DOI: 10.1074/jbc.m116.754887
• 发表时间: 2016-12-30
• 期刊: The Journal of biological chemistry
• 作者: Alvarez-Curto E;Inoue A;Jenkins L;Raihan SZ;Prihandoko R;Tobin AB;Milligan G
• 通讯作者: Milligan G

FFA4/GPR120: Pharmacology and Therapeutic Opportunities.

• DOI: 10.1016/j.tips.2017.06.006
• 发表时间: 2017-09
• 期刊: Trends in pharmacological sciences
• 影响因子: 13.8
• 作者: Milligan G;Alvarez-Curto E;Hudson BD;Prihandoko R;Tobin AB
• 通讯作者: Tobin AB

Chemogenetic analysis of how receptors for short chain fatty acids regulate the gut-brain axis

短链脂肪酸受体如何调节肠脑轴的化学遗传学分析

• DOI: 10.1101/2020.01.11.902726
• 发表时间: 2020
• 作者: Barki N

Chemogenetics defines a short-chain fatty acid receptor gut-brain axis.

化学遗传学定义了短链脂肪酸受体肠脑轴。

• DOI: 10.7554/elife.73777
• 发表时间: 2022-03-01
• 期刊: eLife
• 影响因子: 7.7
• 作者: Barki N;Bolognini D;Börjesson U;Jenkins L;Riddell J;Hughes DI;Ulven T;Hudson BD;Ulven ER;Dekker N;Tobin AB;Milligan G
• 通讯作者: Milligan G

A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias.

• DOI: 10.1074/jbc.m116.736157
• 发表时间: 2016-09-02
• 期刊: The Journal of biological chemistry
• 作者: Bolognini D;Moss CE;Nilsson K;Petersson AU;Donnelly I;Sergeev E;König GM;Kostenis E;Kurowska-Stolarska M;Miller A;Dekker N;Tobin AB;Milligan G
• 通讯作者: Milligan G