Designer Nanoparticles Enable mRNA Protein Factories

设计纳米颗粒使 mRNA 蛋白质工厂成为可能

• 批准号: LP220200939
• 负责人: Prof Chengzhong Yu
• 金额: $ 28万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-10-11 至 2026-10-10
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP220200939
• 关键词: Designer; Nanoparticles; Enable; mRNA; Protein

Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestion and thermal stress. This will be achieved by tailoring the nanochemistry at multi-scales. Expected outcomes include new knowledge in custom-design of functional nanomaterials for mRNA delivery, and new technology that will bring commercial benefits to the partner organisation and the biopharma sector.

mRNA的细胞内传递促进了靶蛋白的生产，这可以建立在生物制造工业中必不可少的蛋白质工厂。然而，mRNA的不稳定性大大降低了蛋白质的生产性能，限制了商业化翻译的潜力。本项目旨在开发新一代纳米颗粒递送系统，以提高mRNA在细胞内不稳定信号、酶消化和热应激下的稳定性。这将通过在多尺度上裁剪纳米化学来实现。预期的成果包括定制设计用于mRNA递送的功能纳米材料的新知识，以及将为合作组织和生物制药部门带来商业利益的新技术。