Designer Nanoparticles Enable mRNA Protein Factories

设计纳米颗粒使 mRNA 蛋白质工厂成为可能

• 批准号: LP220200939
• 负责人: Prof Chengzhong Yu
• 金额: $ 28万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-10-11 至 2026-10-10
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP220200939
• 关键词: Designer; Nanoparticles; Enable; mRNA; Protein

Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestion and thermal stress. This will be achieved by tailoring the nanochemistry at multi-scales. Expected outcomes include new knowledge in custom-design of functional nanomaterials for mRNA delivery, and new technology that will bring commercial benefits to the partner organisation and the biopharma sector.

mRNA的细胞内递送促进靶蛋白的产生，这可以建立在生物制造工业中必不可少的蛋白质工厂。然而，mRNA的不稳定性大大降低了蛋白质生产性能，限制了商业翻译潜力。该项目旨在开发新一代纳米颗粒递送系统，以增强mRNA对细胞内不稳定线索、酶消化和热应激的稳定性。这将通过在多尺度上定制纳米化学来实现。预期成果包括用于mRNA递送的功能性纳米材料的定制设计方面的新知识，以及将为合作伙伴组织和生物制药行业带来商业利益的新技术。