EB-VIRAL IN LATENCY--TRANSFORMATION AND IMMUNE ESCAPE

这项研究的广泛目标是阐明 爱泼斯坦-巴尔病毒(EBV)，特别是它与 这种未被免疫系统识别的病毒，在整个生命周期中 血清阳性的人。我们的发现表明，小而重的B- 淋巴细胞可能含有潜伏的病毒基因组。我们将研究 病毒基因组在这些细胞中的表达，与其 恶性对应的Burkitt淋巴瘤，与急性 体外和体内感染、增殖的原始细胞群体(LCL) (免疫缺陷者中的免疫母细胞性EBV携带淋巴瘤)。调查结果 有望阐明病毒表达的调控，即 不同病毒产物的免疫原性，以及细胞的出现 病毒转录中的表型依赖调节。合在一起考虑 随着我们在Ig/myc易位方面的平行工作，这项工作也将 有助于了解Burkitt淋巴瘤的发展。一份特别的 子项目涉及病毒与上皮细胞的相互作用，在 关于其与鼻咽癌关系的文献记载。

The broad objective of this study is to elucidate the strategy of the Epstein-Barr virus (EBV), particularly as it relates to the persistence of the virus, unrecognized by the immune system, during the entire lifetime of seropositive individuals. Our findings suggest that small heavy B- lymphocytes may harbor the latent viral genome. We shall study the expression of the viral genome in these cells, in comparison with its malignant counterpart, Burkitt's lymphoma, and in contrast to the acutely infected, proliferating blast population in vitro (LCL) and in vivo (immunoblastic EBV-carrying lymphomas in immuno-defectives). The findings are expected to elucidate the regulation of viral expression, the immunogenicity of different viral products, and the occurrence of cell phenotype dependent modulations n viral transcription. Considered together with our parallel work on the Ig/myc translocation, this work will also contribute to the understanding of Burkitt lymphoma development. A special subproject concerns the interactions of the virus with epithelial cells, in view of its documented association with nasopharyngeal carcinoma.