EB-VIRAL IN LATENCY--TRANSFORMATION AND IMMUNE ESCAPE

本研究的主要目标是阐明 EB病毒（EBV），特别是因为它涉及持久性的 在整个生命周期中，免疫系统无法识别病毒， 血清阳性个体。 我们的研究结果表明，小而重的B- 淋巴细胞可能携带潜伏的病毒基因组。 我们将研究 病毒基因组在这些细胞中的表达，与其 恶性对应物伯基特淋巴瘤，与急性 体外和体内感染的增殖母细胞群 （免疫缺陷者中的免疫母细胞性携带EBV的淋巴瘤）。 这些发现 有望阐明病毒表达的调节， 不同病毒产物的免疫原性，以及细胞 表型依赖性调节病毒转录。 一起考虑 与我们对IG/myc易位的平行工作一样，这项工作也将 有助于了解伯基特淋巴瘤的发展。 一个特殊 子项目涉及病毒与上皮细胞的相互作用， 鉴于其与鼻咽癌的相关性。

The broad objective of this study is to elucidate the strategy of the Epstein-Barr virus (EBV), particularly as it relates to the persistence of the virus, unrecognized by the immune system, during the entire lifetime of seropositive individuals. Our findings suggest that small heavy B- lymphocytes may harbor the latent viral genome. We shall study the expression of the viral genome in these cells, in comparison with its malignant counterpart, Burkitt's lymphoma, and in contrast to the acutely infected, proliferating blast population in vitro (LCL) and in vivo (immunoblastic EBV-carrying lymphomas in immuno-defectives). The findings are expected to elucidate the regulation of viral expression, the immunogenicity of different viral products, and the occurrence of cell phenotype dependent modulations n viral transcription. Considered together with our parallel work on the Ig/myc translocation, this work will also contribute to the understanding of Burkitt lymphoma development. A special subproject concerns the interactions of the virus with epithelial cells, in view of its documented association with nasopharyngeal carcinoma.