EPIDEMIOLOGIC STUDY OF LUNG CANCER AND WOOD DUST

肺癌和木尘的流行病学研究

• 批准号: 3198125
• 负责人: THOMAS L VAUGHAN
• 金额: $ 34.27万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-06-01 至 1997-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3198125
• 关键词: adult human (21+); ascorbate; cancer risk; carotene; diet; dust; family genetics; industry; interview; lung neoplasms; male; neoplasm /cancer epidemiology; nutrition related tag; occupational hazard; questionnaires; statistics /biometry; tobacco abuse

A population-based case-control study of lung cancer is proposed to determine if employment in wood-related occupations is associated with increased risk of lung cancer, and to identify specific exposures in these jobs which might explain any increased risks found. Specifically, we will: a) test the hypothesis that persons employed in operational jobs in any of the four major segments of the wood industry are at increased risk of lung cancer; b) test the hypothesis that persons exposed to respirable wood dust in particular, as well as several other potential carcinogens present in wood-related occupations, are at increased risk of lung cancer; and c) determine whether excess risk associated with any of the above factors varies by histologic type, or is modified by other known risk factors such as tobacco use, dietary intake of beta-carotene and vitamin C, or family history of lung cancer. Male cases aged 18-74 years who reside in an 11-county area of western Washington where wood-related occupations are particularly common will be identified from the Cancer Surveillance System of the Fred Hutchinson Cancer Research Center (a SEER registry). Controls of similar age from the same geographic area will be selected by random digit dialing. Approximately 769 cases and an equal number of controls will be interviewed over a three-year period. Subjects will be interviewed by telephone using a structured questionnaire and experienced interviewers. A standard mailed self-administered questionnaire will be used to collect limited dietary information. Exposure to wood dust will be assessed on an individual basis by two industrial hygienists, taking into account job title and typical duties, type of manufactured product, and participation in activities known to produce measurable concentrations of respirable dust. For industries in western Washington in which total and respirable dust levels are not well-characterized, random full-shift sampling will also be accomplished during the first year. Approximately 680 samples will be taken at a minimum of eight industrial sites over two seasons. Stratified analysis and logistic regression will be used to control for the effect of major risk factors and to identify any important effect modification by these factors. Polytomous logistic regression will be used along with pairwise logistic regression to investigate differences in risk among specific histologic types of lung cancer. It is estimated that if wood dust is etiologically related to lung cancer, it may account for 15% of male lung cancer cases in parts of western Washington and 3% nationwide. This would represent approximately 3,000 cases per year in the United States.

本研究拟采用以人群为基础的肺癌病例对照研究， 确定木材相关职业的就业是否与 增加肺癌的风险，并确定这些风险中的特定暴露 可能解释发现的任何风险增加的工作。具体而言，我们将： （a）检验以下假设： 木材工业的四个主要部分患肺癌的风险增加 癌症; B）测试暴露于可吸入木尘的人的假设 特别是，以及存在于 与木材有关的职业，患肺癌的风险增加; c） 确定是否与上述任何因素相关的过度风险 因组织学类型而异，或因其他已知风险因素而改变， 如烟草使用、膳食摄入β-胡萝卜素和维生素C，或家庭 有肺癌病史。 居住在城市的18-74岁男性病例 11-美国华盛顿西部的一个县，与木材有关的职业是 特别常见的是从癌症监测系统中确定的 弗雷德哈钦森癌症研究中心（SEER登记处）。 控制 来自同一地理区域的相似年龄的人将被随机选择 数字拨号 大约769例病例和相同数量的对照 将在三年内接受采访。 受试者将接受采访 通过电话使用结构化问卷和经验丰富的采访者。 将使用标准的邮寄自填问卷收集 有限的饮食信息。 木尘暴露将在 由两名工业企业家根据个人情况， 职务和典型职责、制造产品类型和参与情况 在已知产生可测量浓度的可吸入 灰尘 对于华盛顿西部的工业来说， 粉尘水平没有很好的表征，随机全轮班采样将 也要在第一年完成。 约680份样本将 在两个季节内至少在八个工业地点进行。 分层分析和逻辑回归将用于控制 主要风险因素的影响，并确定任何重要影响 修改这些因素。 将使用多分类logistic回归 沿着成对逻辑回归，以研究风险差异 在特定的组织学类型的肺癌。 估计如果 木尘与肺癌的病因有关，可能占15%。 在华盛顿西部的部分地区，男性肺癌病例占全国的3%。 这将意味着联合国每年约有3 000起案件， States.