Industrial saponins
Industrial saponins
批准号:
BB/M028712/1
负责人:
Anne Osbourn
金额:
$58.68万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2015
资助国家:
英国
项目状态:
已结题
起止时间:
2015 至 --
关键词:
中文摘要
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英文摘要
The aim of this project is to bring saponin production into the domain of industrial biotechnology to make this diverse group of biosurfactants available for commercial exploitation at the required scale, structure specificity & cost, in the first instance for home & personal care (HPC) use. We have already demonstrated that saponins can synergise with conventional surfactants to reduce the total surfactant level required for cleaning performance in laundry detergents, and that such mixtures are particularly effective at low temperatures. Saponins are plant-derived triterpenoidal or steroidal surfactants. Saponins currently have limited commercial availability, being sourced from natural plant materials. This supply is deficient in scale, is of limited structure specificity and is too expensive for Unilever's intended use in laundry detergents. Unilever's concentrated detergents business alone would require 100 tonnes pa of saponin at 0.1% level and 20% product range penetration. Leading saponin supplier Desert King produces only 20 tonnes active saponin pa from natural extracts. Furthermore, we have demonstrated that certain saponin structures are significantly more effective than others. The current sources of saponins are natural extracts and comprise a heterogeneous mixture of saponin structures. Our IB innovation will enable considerable enrichment for the most effective saponin structures. Current commercial saponins are too expensive at $35/kg for crude extracts for use in anything other than premium products. We expect IB to be a more cost effective route to saponin supply.
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DOI:
10.1111/nph.13981
发表时间:
2016-08
期刊:
The New phytologist
影响因子:
--
作者:
[Nützmann HW, Huang A, Osbourn A]
通讯作者:
Osbourn A
DOI:
10.1039/c6np00035e
发表时间:
2016-08-27
期刊:
Natural product reports
影响因子:
11.9
作者:
[Medema MH, Osbourn A]
通讯作者:
Osbourn A
DOI:
10.1038/nchembio.1890
发表时间:
2015-09
期刊:
Nature chemical biology
影响因子:
14.8
作者:
[Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO]
通讯作者:
Glöckner FO
DOI:
10.1016/j.cbpa.2017.04.015
发表时间:
2017-10
期刊:
Current opinion in chemical biology
影响因子:
7.8
作者:
[Owen C, Patron NJ, Huang A, Osbourn A]
通讯作者:
Osbourn A
DOI:
10.1016/j.ymben.2017.06.012
发表时间:
2017-07
期刊:
Metabolic engineering
影响因子:
8.4
作者:
[Reed J, Stephenson MJ, Miettinen K, Brouwer B, Leveau A, Brett P, Goss RJM, Goossens A, O'Connell MA, Osbourn A]
通讯作者:
Osbourn A
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