ANORECTIC DRUGS--ABUSE & BEHAVIORAL MECHANISMS OF ACTION

厌食药物——滥用

• 批准号: 2117011
• 负责人: Richard W Foltin
• 金额: $ 16.63万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-05-01 至 1995-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2117011
• 关键词: anorexic agent; baboons; caloric dietary content; central nervous system stimulants; cholecystokinin; dextroamphetamine; diazepam; drug tolerance; eating; fasting; fenfluramine; nutrition related tag; operant conditionings; phencyclidine; psychopharmacology; sedative /hypnotic; weight control agent

There is increasing concern about the use and misuse of anorectic drugs, with more and more prescribed as adjuncts in weight control therapy. The present proposal will investigate the effects of these drugs on patterns of food intake in baboons maintained under minimal deprivation conditions. Food will be continuously available under an operant schedule that differentiates patterning of meals from pattern of pellet intake within meals. Schedule parameters will be chosen so that each animal will have control over initiation as well as termination of feeding throughout the day. Baseline patterns of food intake will be determined by measuring meal frequency, size, duration, and distribution of intake within each meal over several months. The effects of four manipulations on feeding will be assessed in order to compare those effects with later drug effects. Caloric prefeeding, acute deprivation cholecystokinin administration and the availability of an alternate energy source will all be parametrically manipulated. Complete dose-response functions for six amphetamine-like/stimulant anorectic drugs, three fenfluramine-like/sedative anorectic drugs and phenylpropanolamine will be determined. In addition, diazepam, known to increase food intake, and phencyclidine, which should decrease food intake by causing motor deficits, will also be tested. Profiles of the behavioral mechanisms of all these drugs when given on a single dose basis will be developed. Furthermore, the work will analyze the effects of long-term administration of low doses of d-amphetamine and fenfluramine on food intake; cross-tolerance to each other, phenylpropanolamine, and phencyclidine will be examined. The data collected in these studies will enhance the abuse liability data base of the anorectics and, in addition, provide important information about their behavioral mechanisms. This research will add to the large experimental data base on the self-administration of these compounds in primates, and provide important information for the analysis of the behavioral mechanisms of these drugs, e.g., effects on meal size and patterning. Such information will be useful both in evaluation of therapeutic efficacy and in understanding the basic processes involved in eating behavior.

人们越来越关注厌食药物的使用和滥用， 越来越多的处方作为减肥治疗的辅助药物。 的 目前的建议将调查这些药物对模式的影响， 狒狒的食物摄入量维持在最低限度的剥夺条件下。 食物将根据操作时间表持续供应， 区分膳食模式和颗粒摄入模式， 吃饭。 将选择时间表参数，以便每只动物 在整个过程中控制喂食的开始和终止 天 将通过测量膳食来确定食物摄入的基线模式 频率、大小、持续时间和每餐内的摄入量分布 几个月 四种操作对喂养的影响将是 评估以将这些效果与后来的药物效果进行比较。 热量预喂养，急性剥夺胆囊收缩素管理和 替代能源可用性将全部是参数化的 被操纵了 完成六个剂量反应函数 安非他明类/兴奋剂厌食药物，三种 芬氟拉明类/镇静厌食药物和苯丙醇胺将被 测定 此外，安定，已知增加食物摄入量， 苯环利定，它应该通过引起运动缺陷来减少食物摄入， 也将受到考验。 所有这些行为机制的概况 将开发单剂量给药的药物。 此外，委员会认为， 这项工作将分析长期服用低剂量药物的影响， d-安非他明和芬氟拉明对食物摄入量的影响;对每种药物的交叉耐受性 其他，苯丙醇胺和苯环己哌啶将被检查。 数据 这些研究中收集的数据将增强 此外，还提供了关于其 行为机制 这项研究将增加大型实验 这些化合物在灵长类动物中自我给药的数据库，以及 为行为机制的分析提供重要信息 在这些药物中，例如，对膳食大小和模式的影响。 等 这些信息将有助于评价治疗效果， 对理解进食行为的基本过程有很大帮助