SIMULATION OF IV DRUG EFFECTS ON HIV INFECTIONS AND AIDS
SIMULATION OF IV DRUG EFFECTS ON HIV INFECTIONS AND AIDS
批准号:
3211259
负责人:
Philip C Cooley
金额:
$22.02万
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-09-30 至 1990-08-31
关键词:
AIDS behavior modification blood transfusion communicable disease transmission computer simulation congenital infection disease /disorder prevention /control disease /disorder proneness /risk drug abuse education education evaluation /planning epidemiology health education hemophilia As human immunodeficiency virus 1 immunopathology chemotherapy information display intravenous drug abuse mathematical model model design /development perinatal placental transfer serology /serodiagnosis sex behavior sexually transmitted diseases social group process viral vaccines
中文摘要
拟议研究的主要目标是开发一种
预测艾滋病毒感染流行程度的计算机模型
以及艾滋病毒向艾滋病的发展。一个重要的
该模型的特点将是描绘静脉注射毒品在
艾滋病的传播。尤其是静脉注射吸毒者的影响
关于艾滋病毒向艾滋病传播的异性恋高危人群
检查过了。总而言之,拟议的研究将:
O艾滋病毒和艾滋病在总人口中的流行率项目
O项目艾滋病毒流行率和艾滋病的比例
静脉注射吸毒者的个案
O项目因使用静脉注射药物而导致的新感染人数
O预测受感染的异性恋人口的规模
O在异性恋高危人群中规划新的艾滋病毒感染
是由静脉注射吸毒者传播的。
一般来说,疾病的传播特征是高度
因此,非线性和结果是违反直觉的。识别
管理艾滋病流行的适当政策在以下方面至关重要
这一次。然而,对现有艾滋病模型的依赖被发现
在文学上是不合适的。主要原因是很多人
的模型和/或模型参数与历史相关联
行为模式。因此,它们不能直接说明:
O所有主要传播途径,即同性恋者
接触、静脉注射毒品和异性接触
O传输中断与控制之间的联系
诸如教育宣传方案或疫苗和
治疗方案
O影响的主要风险群体特征行为
传输
O观察到的影响行为改变的趋势
变速箱。
拟议的计算机模型将考虑到上述所有因素。
英文摘要
The major objective of the proposed research is to develop a
computer model that predicts the prevalence of the HIV infection
and the progression of HIV to the AIDS disease. A significant
feature of the model will be to portray the role of IV drug use in
the spread of AIDS. In particular, the influence of IV drug users
on the spread of HIV to AIDS heterosexual risk groups will be
examined. In summary, the proposed research will:
o Project HIV and AIDS disease prevalence in the total population
o Project the proportion of the HIV prevalence and AIDS disease
cases that are IV drug users
o Project the number of new infections resulting from IV drug use
o Project the size of the infected heterosexual population
o Project the new HIV infections in the heterosexual risk group
that are spread by IV drug users.
Disease transmission characteristics in general are highly
nonlinear and as a consequence are counter intuitive. Identifying
appropriate policies for managing the AIDS epidemic is critical at
this time. However, reliance on existing AIDS models identified
in the literature is inappropriate. The major reason is that many
of the models and/or model parameters are wedded to historical
behavior patterns. As a result, they do not directly account for:
o All of the primary transmission routes, i.e., homosexual
contact, IV drug use, and heterosexual contact
o The linkages between transmission interruption and control
strategies such as education awareness programs or vaccines and
therapy programs
o The major risk group characteristics behavior that influence
transmission
o Observed trends in behavior modification that are influencing
transmission.
The proposed computer model will account for all of the above.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
MIDAS ITR Extension
-
批准号:8848244
-
项目类别:
-
资助金额:$9.96万
-
财政年份:2014
-
负责人:Philip C Cooley
-
依托单位:
Modeling of Infectious Disease Agent Study Information Technology
-
批准号:8481558
-
项目类别:
-
资助金额:$190.71万
-
财政年份:2009
-
负责人:Philip C Cooley
-
依托单位:
SIMULATION OF IV DRUG INTERVENTIONS ON HIV INFECT/AIDS
-
批准号:3211260
-
项目类别:
-
资助金额:$29.41万
-
财政年份:1987
-
负责人:Philip C Cooley
-
依托单位:
IMULATION OF IV DRUG INTERVENTIONS ON HIV INFECTIONS &
-
批准号:3211258
-
项目类别:
-
资助金额:$28.87万
-
财政年份:1987
-
负责人:Philip C Cooley
-
依托单位:
SIMULATION OF IV DRUG EFFECTS ON HIV INFECTIONS AND AIDS
-
批准号:3211255
-
项目类别:
-
资助金额:$18.51万
-
财政年份:1987
-
负责人:Philip C Cooley
-
依托单位:
海外基金