TOOTH ENAMEL APATITE AT THE ATOMIC LEVEL

原子水平的牙釉质磷灰石

• 批准号: 3218771
• 负责人: ROBERT A YOUNG
• 金额: $ 20.83万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-05-01 至 1987-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3218771
• 关键词: X ray crystallography; apatites; carbonates; chemical structure; chemical substitution; chlorine; dental caries inhibitor; diffusion; hydroxyapatites; hydroxyl group; infrared spectrometry; lead; magnesium; manganese; molecular biology; neutron diffraction; phosphates; preventive dentistry; respiratory oxygen; sodium; stoichiometry; strontium; tooth enamel; topical fluoride therapy; water; zinc; zirconium

The long-term goal is the elucidation, at the atomic level, of phenomena and mechanisms important to the understanding and ultimate modification of the biological occurrence, function and dysfunction of the apatitic portion of dental hard tissue. Various atomic/ionic species present in human tooth enamel (TE) are being studied (1) for their precise structural locations and roles and (2) for the atomic-scale mechanisms by which they affect diffusion, acid dissolution, and the response of TE to various treatments and environments. The structural model for the crystalline portion of TE is constantly being improved toward realism as the locations and roles are further clarified for CO 2 over 3 minus, HPO 2 over 4 minus, H2O, Na ion, Mg 2ion, Sr 2ion Zn 2ion, Pb 2ion, vacancies, and for C1 minus, F minus and oxygen substituting for them. Principal experimental methods are x-ray and neutron diffraction (especially Rietveld analysis), i.r. spectroscopy, deuterizability, EXAFS, and various chemical preparation and analysis methods. Studies are carried out both directly on TE and on related apatite compounds.

长期目标是在原子水平上阐明各种现象， 对理解和最终修改《公约》 磷灰石部分的生物学发生、功能和功能障碍 牙齿硬组织 人类牙釉质中存在的各种原子/离子种类 (TE)正在研究（1）它们的精确结构位置和作用， (2)对于它们影响扩散的原子尺度机制，酸 溶解，以及TE对各种处理和环境的响应。 的 TE结晶部分的结构模型不断得到改进 随着CO2浓度超过3的位置和作用的进一步澄清， HPO 2 > 4-、H2O、Na离子、Mg 2+、Sr 2+、Zn 2+、Pb 2+、 空位，以及C1-，F-和氧取代它们。 主要的实验方法是X射线和中子衍射（特别是 Rietveld分析），i.r.光谱，氘化，EXAFS，和各种 化学制备和分析方法。 两项研究都进行了 直接作用在TE和相关的磷灰石化合物上。

项目成果

Variability of hydroxyapatite preparations.

羟基磷灰石制剂的可变性。

• 发表时间: 1982
• 期刊: Calcified tissue international
• 影响因子: 4.2
• 作者: Young,RA;Holcomb,DW
• 通讯作者: Holcomb,DW

Role of acid phosphate in hydroxyapatite lattice expansion.

酸性磷酸盐在羟基磷灰石晶格膨胀中的作用。

• DOI: 10.1007/bf02405294
• 发表时间: 1984
• 期刊: Calcified tissue international
• 影响因子: 4.2
• 作者: Young,RA;Holcomb,DW
• 通讯作者: Holcomb,DW

Reorientable electric dipoles and cooperative phenomena in human tooth enamel.

人类牙釉质中的可重新定向电偶极子和合作现象。

• DOI: 10.1007/bf02556603
• 发表时间: 1986
• 期刊: Calcified tissue international
• 影响因子: 4.2
• 作者: Hitmi,N;Lamure-Plaino,E;Lamure,A;LaCabanne,C;Young,RA
• 通讯作者: Young,RA