Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites

氟化二氨银对磷灰石微观结构-功能的影响

• 批准号: LP180101352
• 负责人: Prof Michael Swain
• 金额: $ 27.56万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-12-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP180101352
• 关键词: Microstructural; Functional; Effect; Silver; Diammine

This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical evidence on the underlying mechanisms, alternative protocols, delivery systems enable to optimise the treatment. The scientific insights into arresting/repairing damage processes will provide critical data for developing minimal intervention protocols for pediatric and geriatric populations.

该项目旨在在纳米结构水平上对银二氨氟化物（SDF）治疗后牙本质和牙釉质的矿化和机械性能增强的因素进行基本了解。将使用各种先进的纳米机械、断层扫描和显微镜技术来处理声音、龋齿和SDF治疗的组织。关于潜在机制、替代方案、输送系统的新生物力学证据能够优化治疗。对阻止/修复损伤过程的科学见解将为制定儿科和老年人群的最小干预方案提供关键数据。