SENSITIZATION TO COCAINE

对可卡因的敏感性

• 批准号: 3213545
• 负责人: SUSAN PICKETT
• 金额: $ 12.89万
• 依托单位: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3213545
• 关键词: amphetamines; biological models; caffeine; catheterization; cocaine; dopamine; drug abuse; drug administration rate /duration; drug hypersensitivity; frontal lobe /cortex; jugular veins; laboratory rat; microdialysis; neurochemistry; neuropharmacologic agent; nicotine; nucleus accumbens; psychomotor function; reinforcer; self destructive behavior; sensorimotor system; statistics /biometry; stimulant /agonist

It is the purpose of these experiments to examine the process of sensitization to cocaine following pretreatment with a number of pharmacological agents. It is our aim to evaluate the idea that at least part of the basis for variability in response to the rewarding effects of cocaine Is due to differences in the development of specific neurochemical systems, which in turn is due to environmental conditions. Rats will be exposed to four compounds (nicotine, caffeine, cocaine or amphetamine) for various periods of time. We will compare the ability for exposure to these compounds to alter the motor activating effects of cocaine and the propensity to self-administer this drug. Should the results show that preexposure to some agents can after the acquisition of cocaine self-administration, they will provide us with a realistic approach to prevention of abuse of this compound. We will also examine the neurochemical basis for changes in sensitivity produced by the preexposure regimen using microdialysis probes to measure the changes in extracellular dopamine within the nucleus accumbens and medial prefrontal cortex. Taken together, it is our hope that this line of investigation will demonstrate the importance of environmental factors as predisposing to drug abuse and will provide avenues leading to prevention of this compulsive self-destructive behavior.

这些实验的目的是检验这个过程 经过一些预处理后对可卡因过敏 药理制剂。 我们的目标是评估这个想法，至少 响应奖励效应的可变性的一部分基础 可卡因 是由于特定发育的差异 神经化学系统，这又是由于环境条件造成的。 老鼠将接触四种化合物（尼古丁、咖啡因、可卡因或 安非他明）在不同时期。 我们将比较能力 暴露于这些化合物以改变运动激活效果 可卡因和自我服用这种药物的倾向。 应该 结果表明，预先暴露于某些药剂可以在获得后 可卡因自我管理，他们将为我们提供现实的 防止滥用该化合物的方法。 我们还将检查 敏感性变化的神经化学基础 使用微透析探针测量暴露前方案的变化 伏隔核和内侧前额叶内的细胞外多巴胺 皮质。 总而言之，我们希望这一调查线 将证明环境因素作为诱发因素的重要性 并提供预防药物滥用的途径 强迫性的自我毁灭行为。